Thrombin generation parameters in f10WT mice and f10low mice: effect of fitusiran
| . | No extra FX . | With 2% FX . | ||||
|---|---|---|---|---|---|---|
| f10low (n = 9) . | f10low + fitusiran (n = 4) . | P value . | f10low (n = 3) . | f10low + fitusiran (n = 4) . | P value . | |
| Lag time (min) | 7.0 ± 2.8 | 3.3 ± 1.6 | .033 | 2.3 ± 0.6 | 3.8 ± 2.5 | .365 |
| ETP (nM·min) | 149 ± 126 | 904 ± 404 | .0002 | 783 ± 463 | 1724 ± 260 | .018 |
| Peak thrombin (nM) | 14 ± 8 | 36 ± 20 | .014 | 32 ± 11 | 59 ± 10 | .019 |
| Time to peak (min) | 12 ± 6 | 13 ± 1 | .752 | 13 ± 6 | 17 ± 5 | .379 |
| . | No extra FX . | With 2% FX . | ||||
|---|---|---|---|---|---|---|
| f10low (n = 9) . | f10low + fitusiran (n = 4) . | P value . | f10low (n = 3) . | f10low + fitusiran (n = 4) . | P value . | |
| Lag time (min) | 7.0 ± 2.8 | 3.3 ± 1.6 | .033 | 2.3 ± 0.6 | 3.8 ± 2.5 | .365 |
| ETP (nM·min) | 149 ± 126 | 904 ± 404 | .0002 | 783 ± 463 | 1724 ± 260 | .018 |
| Peak thrombin (nM) | 14 ± 8 | 36 ± 20 | .014 | 32 ± 11 | 59 ± 10 | .019 |
| Time to peak (min) | 12 ± 6 | 13 ± 1 | .752 | 13 ± 6 | 17 ± 5 | .379 |