Thrombin generation parameters in f10WT mice and f10low mice: effect of initiator (TF vs factor XIa)
| . | TF (1 pM) . | Factor XIa (0.15 nM) . | ||||
|---|---|---|---|---|---|---|
| f10WT (n = 9) . | f10low (n = 9) . | P value . | f10WT (n = 7) . | f10low (n = 6) . | P value . | |
| Lag time (min) | 1.0 ± 0.3 | 7.0 ± 2.8 | <.0001 | 1.4 ± 0.6 | 15 ± 8 | .0009 |
| ETP (nM·min) | 1020 ± 96 | 149 ± 126 | <.0001 | 1103 ± 174 | 109 ± 96 | <.0001 |
| Peak thrombin (nM) | 111 ± 11 | 14 ± 8 | <.0001 | 164 ± 16 | 10 ± 8 | <.0001 |
| Time to peak (min) | 3.0 ± 0.6 | 12 ± 6 | .0004 | 3.0 ± 0.6 | 18 ± 7 | .0001 |
| . | TF (1 pM) . | Factor XIa (0.15 nM) . | ||||
|---|---|---|---|---|---|---|
| f10WT (n = 9) . | f10low (n = 9) . | P value . | f10WT (n = 7) . | f10low (n = 6) . | P value . | |
| Lag time (min) | 1.0 ± 0.3 | 7.0 ± 2.8 | <.0001 | 1.4 ± 0.6 | 15 ± 8 | .0009 |
| ETP (nM·min) | 1020 ± 96 | 149 ± 126 | <.0001 | 1103 ± 174 | 109 ± 96 | <.0001 |
| Peak thrombin (nM) | 111 ± 11 | 14 ± 8 | <.0001 | 164 ± 16 | 10 ± 8 | <.0001 |
| Time to peak (min) | 3.0 ± 0.6 | 12 ± 6 | .0004 | 3.0 ± 0.6 | 18 ± 7 | .0001 |
Data represent mean ± SD. Statistical analysis was performed using unpaired Student t test, and Welch correction was applied where necessary.