Table 6.

Multivariate analysis of factors affecting OS in MPN-AP/BP

VariableHR (95% CI)P value
Age ≥ 65 y 1.870 (1.265, 2.765) .002 
WBC > 25 × 109/L 2.354 (1.589, 3.488) < .0001 
Platelet > 100 × 109/L 0.443 (0.272, 0.723) .001 
Hemoglobin > 10 g/dL vs < 8 g/dL 0.629 (0.425, 0.929) .02 
TP53 mutation status 2.146 (1.460, 3.153) .0001 
Splenomegaly 1.305 (0.925, 1.842) .13 
VariableHR (95% CI)P value
Age ≥ 65 y 1.870 (1.265, 2.765) .002 
WBC > 25 × 109/L 2.354 (1.589, 3.488) < .0001 
Platelet > 100 × 109/L 0.443 (0.272, 0.723) .001 
Hemoglobin > 10 g/dL vs < 8 g/dL 0.629 (0.425, 0.929) .02 
TP53 mutation status 2.146 (1.460, 3.153) .0001 
Splenomegaly 1.305 (0.925, 1.842) .13 
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