Table 1. In vitro cytotoxic synergy... | American Society of Hematology

Table 1.

In vitro cytotoxic synergy induced by the combination of VEN and A1155463

Sample	A1155463 (nM)	VEN (nM)	CI	Sample	A1155463 (nM)	VEN (nM)	CI	Sample	A1155463 (nM)	VEN (nM)	CI
MCL				DLBCL				ALL
	1000	1	0.150		100	100	0.214		1000	100	0.128
HBL-2	1000	2.5	0.284	UPF29TO	1000	100	0.151	UPF24F	1000	500	0.083
	1000	5	0.521		1000	1000	0.547		1000	1000	0.103
	1000	5	0.266	DB	1000	100	0.211	UPF25R	1000	50	0.046
MAVER-1	1000	10	0.294		1000	500	0.156		1000	100	0.031
	1000	20	0.347		1000	1000	0.099		1000	500	0.093
	1000	50	0.009	OCI-LY19	1000	100	0.113	UPF26K	1000	10	0.147
UPF1H	1000	100	0.005		1000	500	0.242		1000	50	0.071
	1000	200	0.003		1000	1000	0.177		1000	100	0.065
	1000	10	1.46E−04	SU-DHL4	1000	100	0.076	UPF27L	1000	50	0.568
MINO	1000	50	5.61E−04		1000	500	0.023		1000	100	0.429
	1000	100	8.62E−04		1000	1000	0.019		1000	500	0.649
	100	100	5.52E−04	HBL-1	1000	100	0.033	UPF31A	1000	100	0.142
JEKO-1	1000	100	3.56E−04		1000	500	0.125		1000	500	0.052
	1000	1000	1.15E−03		1000	1000	0.156		1000	1000	0.048
	100	100	0.264	OCI-LY3	1000	100	0.145	UPF34N	1000	10	0.350
REC-1	1000	100	0.559		1000	500	0.075		1000	20	0.229
	1000	1000	0.185		1000	1000	0.145		1000	40	0.252
	100	100	3.01E−09	U2932	1000	100	0.532	UPF35S	1000	10	0.068
Z-138	1000	100	9.90E−10		1000	500	0.401		1000	50	0.046
	1000	1000	4.96E−08		1000	1000	0.541		1000	100	0.066

Sample	A1155463 (nM)	VEN (nM)	CI	Sample	A1155463 (nM)	VEN (nM)	CI	Sample	A1155463 (nM)	VEN (nM)	CI
MCL				DLBCL				ALL
	1000	1	0.150		100	100	0.214		1000	100	0.128
HBL-2	1000	2.5	0.284	UPF29TO	1000	100	0.151	UPF24F	1000	500	0.083
	1000	5	0.521		1000	1000	0.547		1000	1000	0.103
	1000	5	0.266	DB	1000	100	0.211	UPF25R	1000	50	0.046
MAVER-1	1000	10	0.294		1000	500	0.156		1000	100	0.031
	1000	20	0.347		1000	1000	0.099		1000	500	0.093
	1000	50	0.009	OCI-LY19	1000	100	0.113	UPF26K	1000	10	0.147
UPF1H	1000	100	0.005		1000	500	0.242		1000	50	0.071
	1000	200	0.003		1000	1000	0.177		1000	100	0.065
	1000	10	1.46E−04	SU-DHL4	1000	100	0.076	UPF27L	1000	50	0.568
MINO	1000	50	5.61E−04		1000	500	0.023		1000	100	0.429
	1000	100	8.62E−04		1000	1000	0.019		1000	500	0.649
	100	100	5.52E−04	HBL-1	1000	100	0.033	UPF31A	1000	100	0.142
JEKO-1	1000	100	3.56E−04		1000	500	0.125		1000	500	0.052
	1000	1000	1.15E−03		1000	1000	0.156		1000	1000	0.048
	100	100	0.264	OCI-LY3	1000	100	0.145	UPF34N	1000	10	0.350
REC-1	1000	100	0.559		1000	500	0.075		1000	20	0.229
	1000	1000	0.185		1000	1000	0.145		1000	40	0.252
	100	100	3.01E−09	U2932	1000	100	0.532	UPF35S	1000	10	0.068
Z-138	1000	100	9.90E−10		1000	500	0.401		1000	50	0.046
	1000	1000	4.96E−08		1000	1000	0.541		1000	100	0.066

CI, combination index.