Baseline characteristics of the patient cohorts
| Parameter . | Cohort 1 (n = 27) . | Cohort 2 (n = 45) . | P value . |
|---|---|---|---|
| Median age (range), y | 70 (51-88) | 69 (39-88) | .40 |
| Sex, % (n) | .63 | ||
| Male | 63 (17) | 56 (25) | |
| Female | 37 (10) | 44 (20) | |
| Race, % (n) | .38 | ||
| White | 85 (23) | 73 (33) | |
| Black | 7 (2) | 22 (10) | |
| Weight (range), kg | 72 (47-122) | 75 (48-127) | .85 |
| MM type, % (n) | .33 | ||
| FKLC | 7 (2) | 11 (5) | |
| FLLC | 11 (3) | 7 (3) | |
| IgA kappa | 15 (4) | 7 (3) | |
| IgA lambda | 15 (4) | 13 (6) | |
| IgG kappa | 33 (9) | 47 (21) | |
| IgG lambda | 19 (5) | 13 (6) | |
| Other | 2 (1) | ||
| High-risk cytogenetics∗, % (n) | 70 (19) | 38 (17) | .01 |
| Median prior lines of therapy (range) | 8 (4-13) | 5 (3-14) | .03 |
| Extramedullary disease, % (n) | 33 (9) | 27 (12) | .60 |
| Elevated LDH (before teclistamab), % (n) | 30 (8) | 31 (14) | 1.00 |
| Autologous transplant, % (n) | 70 (19) | 64 (29) | .36 |
| Allogeneic transplant, % (n) | 11 (3) | 1 (2) | .15 |
| Parameter . | Cohort 1 (n = 27) . | Cohort 2 (n = 45) . | P value . |
|---|---|---|---|
| Median age (range), y | 70 (51-88) | 69 (39-88) | .40 |
| Sex, % (n) | .63 | ||
| Male | 63 (17) | 56 (25) | |
| Female | 37 (10) | 44 (20) | |
| Race, % (n) | .38 | ||
| White | 85 (23) | 73 (33) | |
| Black | 7 (2) | 22 (10) | |
| Weight (range), kg | 72 (47-122) | 75 (48-127) | .85 |
| MM type, % (n) | .33 | ||
| FKLC | 7 (2) | 11 (5) | |
| FLLC | 11 (3) | 7 (3) | |
| IgA kappa | 15 (4) | 7 (3) | |
| IgA lambda | 15 (4) | 13 (6) | |
| IgG kappa | 33 (9) | 47 (21) | |
| IgG lambda | 19 (5) | 13 (6) | |
| Other | 2 (1) | ||
| High-risk cytogenetics∗, % (n) | 70 (19) | 38 (17) | .01 |
| Median prior lines of therapy (range) | 8 (4-13) | 5 (3-14) | .03 |
| Extramedullary disease, % (n) | 33 (9) | 27 (12) | .60 |
| Elevated LDH (before teclistamab), % (n) | 30 (8) | 31 (14) | 1.00 |
| Autologous transplant, % (n) | 70 (19) | 64 (29) | .36 |
| Allogeneic transplant, % (n) | 11 (3) | 1 (2) | .15 |
FKLC, free kappa light chain; FLLC, free lambda light chain; IgA, immunoglobulin A; IgG, immunoglobulin G; LDH, lactate dehydrogenase.
t(4;14), t(14;16), t(14;20), TP53 mutations, 17p deletions, and 1q gain/amplifications.