Univariable analysis for PFS and OS in patients with CCUS
| Variables . | PFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Exposure to therapy | 2.11 (1.22-3.63) | .007 | 2.33 (1.27-4.31) | .007 |
| Age | 1.02 (1.00-1.04) | .077 | 1.03 (1.01-1.10) | .046 |
| Sex (male) | 1.28 (0.73-2.24) | .395 | 1.07 (0.57-2.00) | .833 |
| Active or A | 1.10 (0.65-1.87) | .728 | 0.95 (0.52-1.74) | .876 |
| Hb | 0.78 (0.69-0.89) | <.001 | 0.74 (0.63-0.86) | <.001 |
| WBC | 1.00 (0.93-1.08) | .936 | 1.03 (0.96-1.11) | .420 |
| PLT | 0.99 (0.99-0.99) | .022 | 0.99 (0.99-0.99) | .023 |
| ANC | 1.02 0.92-1.12) | .754 | 1.06 (0.96-1.18) | .221 |
| AMC | 1.10 (0.73-1.65) | .667 | 1.25 (0.84-1.87) | .264 |
| RDW | 1.18 (1.10-1.26) | <.001 | 1.20 (1.11-1.29) | <.001 |
| MCV | 1.03 (1.00-1.06) | .022 | 1.03 (0.99-1.06) | .059 |
| Abnormal cytogenetics | 1.55 (0.88-2.73) | .132 | 1.93 (1.04-3.59) | .040 |
| Bone marrow blasts | 1.15 (0.91-1.45) | .236 | 1.24 (0.96-1.59) | .098 |
| Number of mutations | 1.15 (0.90-1.48) | .259 | 1.18 (0.90-1.56) | .237 |
| CHRS score | 1.37 (1.18-1.59) | <.001 | 1.29 (1.10-1.51) | .002 |
| Maximum VAF | 0.98 (0.97-0.99) | .043 | 0.99 (0.97-1.00) | .144 |
| TET2 mutated | 0.97 (0.56-1.68) | .923 | 0.87 (0.46-1.61) | .649 |
| SRSF2 mutated | 1.25 (0.68-2.28) | .478 | 1.23 (0.62-2.43) | .559 |
| ASXL1 mutated | 1.02 (0.48-2.15) | .966 | 1.17 (0.52-2.63) | .704 |
| DNMT3A mutated | 1.07 (0.48-2.37) | .868 | 1.16 (0.49-2.76) | .730 |
| ZRSR2 mutated | 1.19 (0.51-2.79) | .684 | 0.89 (0.32-2.49) | .820 |
| U2AF1 mutated | 2.06 (0.97-4.39) | .061 | 2.15 (0.95-4.83) | .065 |
| TP53 mutated | 2.66 (1.14-6.24) | .024 | 3.29 (1.28-8.43) | .013 |
| SF3B1 mutated | 3.86 (1.2-12.50) | .024 | 0.73 (0.10-5.31) | .755 |
| RUNX1 mutated | 1.46 (0.45-4.67) | .526 | 1.94 (0.60-6.30) | .268 |
| DAT∗ mutation | 0.88 (0.52-1.49) | .633 | 0.78 (0.43-1.41) | .412 |
| Spliceosome factor mutation | 1.68 (0.99-2.84) | .053 | 1.18 (0.65-2.15) | .585 |
| Epigenetic regulator mutation | 0.90 (0.53-1.53) | .702 | 0.85 (0.47-1.53) | .588 |
| Cell signaling mutation | 0.77 (0.33-1.80) | .550 | 0.83 (0.33-2.11) | .695 |
| Variables . | PFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Exposure to therapy | 2.11 (1.22-3.63) | .007 | 2.33 (1.27-4.31) | .007 |
| Age | 1.02 (1.00-1.04) | .077 | 1.03 (1.01-1.10) | .046 |
| Sex (male) | 1.28 (0.73-2.24) | .395 | 1.07 (0.57-2.00) | .833 |
| Active or A | 1.10 (0.65-1.87) | .728 | 0.95 (0.52-1.74) | .876 |
| Hb | 0.78 (0.69-0.89) | <.001 | 0.74 (0.63-0.86) | <.001 |
| WBC | 1.00 (0.93-1.08) | .936 | 1.03 (0.96-1.11) | .420 |
| PLT | 0.99 (0.99-0.99) | .022 | 0.99 (0.99-0.99) | .023 |
| ANC | 1.02 0.92-1.12) | .754 | 1.06 (0.96-1.18) | .221 |
| AMC | 1.10 (0.73-1.65) | .667 | 1.25 (0.84-1.87) | .264 |
| RDW | 1.18 (1.10-1.26) | <.001 | 1.20 (1.11-1.29) | <.001 |
| MCV | 1.03 (1.00-1.06) | .022 | 1.03 (0.99-1.06) | .059 |
| Abnormal cytogenetics | 1.55 (0.88-2.73) | .132 | 1.93 (1.04-3.59) | .040 |
| Bone marrow blasts | 1.15 (0.91-1.45) | .236 | 1.24 (0.96-1.59) | .098 |
| Number of mutations | 1.15 (0.90-1.48) | .259 | 1.18 (0.90-1.56) | .237 |
| CHRS score | 1.37 (1.18-1.59) | <.001 | 1.29 (1.10-1.51) | .002 |
| Maximum VAF | 0.98 (0.97-0.99) | .043 | 0.99 (0.97-1.00) | .144 |
| TET2 mutated | 0.97 (0.56-1.68) | .923 | 0.87 (0.46-1.61) | .649 |
| SRSF2 mutated | 1.25 (0.68-2.28) | .478 | 1.23 (0.62-2.43) | .559 |
| ASXL1 mutated | 1.02 (0.48-2.15) | .966 | 1.17 (0.52-2.63) | .704 |
| DNMT3A mutated | 1.07 (0.48-2.37) | .868 | 1.16 (0.49-2.76) | .730 |
| ZRSR2 mutated | 1.19 (0.51-2.79) | .684 | 0.89 (0.32-2.49) | .820 |
| U2AF1 mutated | 2.06 (0.97-4.39) | .061 | 2.15 (0.95-4.83) | .065 |
| TP53 mutated | 2.66 (1.14-6.24) | .024 | 3.29 (1.28-8.43) | .013 |
| SF3B1 mutated | 3.86 (1.2-12.50) | .024 | 0.73 (0.10-5.31) | .755 |
| RUNX1 mutated | 1.46 (0.45-4.67) | .526 | 1.94 (0.60-6.30) | .268 |
| DAT∗ mutation | 0.88 (0.52-1.49) | .633 | 0.78 (0.43-1.41) | .412 |
| Spliceosome factor mutation | 1.68 (0.99-2.84) | .053 | 1.18 (0.65-2.15) | .585 |
| Epigenetic regulator mutation | 0.90 (0.53-1.53) | .702 | 0.85 (0.47-1.53) | .588 |
| Cell signaling mutation | 0.77 (0.33-1.80) | .550 | 0.83 (0.33-2.11) | .695 |
Variables in bold indicate P < 0.05. MCV, mean corpuscular volume; PLT, platelets; WBC, white blood cell count.
DAT mutations: DNMT3A, ASXL1, and TET2.