Serum concentrations (pg/mL) of cytokines between patients with TAM with or without a high WBC count
| . | Patients with a high WBC count∗, n = 29 . | Patients without a high WBC count, n = 99 . | P value† . |
|---|---|---|---|
| IL-1b, median (range) | 3.13 (1.42-325.2) | 2.49 (0.63-3662) | .005 |
| IL-1ra | 211.6 (19.71-868.1) | 116.0 (8.85-9285) | .064 |
| IL-4 | 4.06 (1.69-10.43) | 3.79 (0.89-32.97) | .698 |
| IL-5 | 2.295 (0.11-16.44) | 2.47 (0.06-20.88) | .625 |
| IL-6 | 117.9 (8.49-1537.9) | 33.70 (1.75-6851) | .003 |
| IL-7 | 31.67 (4.91-613.2) | 12.10 (0.97-184.5) | .007 |
| IL-8 | 93.43 (19.42-8350) | 44.97 (8.81-37418) | .023 |
| IL-9 | 26.71 (2.46-130.8) | 21.89 (1.26-250.6) | .225 |
| IL-10 | 14.69 (5.36-260.5) | 11.62 (1.56-170.6) | .066 |
| IL-13 | 19.84 (1.01-123.0) | 8.980 (0.58-199.2) | .029 |
| Eotaxin | 176.7 (48.34-2265) | 148.4 (12.50-892.0) | .090 |
| PDGF-bb | 5610 (300.0-18523) | 4459 (61.75-18489) | .060 |
| Basic FGF | 60.79 (16.31-935.3) | 47.42 (6.77-254.3) | .079 |
| G-CSF | 65.73 (25.02-7232) | 55.71 (9.39-1770) | .078 |
| GM-CSF | 173.8 (47.04-851.1) | 132.0 (6.05-1836) | .081 |
| IFN-r | 93.31 (16.52-597.9) | 74.79 (10.22-6328) | .606 |
| IP-10 | 2011 (296.0-18554) | 1742 (70.84-18686) | .602 |
| MCP-1(MCAF) | 617.2 (86.33-4051) | 195.8 (31.28-10398) | .020 |
| MIP-1a | 7.710 (0.53-759.1) | 6.640 (0.71-565.6) | .460 |
| MIP-1b | 380.7 (121.7-4387) | 280.1 (59.98-50908) | .229 |
| TNF-a | 50.40 (21.43-362.8) | 40.81 (10.23-1029) | .216 |
| VEGF | 112.6 (12.17-1974) | 76.85 (8.27-4490) | .083 |
| . | Patients with a high WBC count∗, n = 29 . | Patients without a high WBC count, n = 99 . | P value† . |
|---|---|---|---|
| IL-1b, median (range) | 3.13 (1.42-325.2) | 2.49 (0.63-3662) | .005 |
| IL-1ra | 211.6 (19.71-868.1) | 116.0 (8.85-9285) | .064 |
| IL-4 | 4.06 (1.69-10.43) | 3.79 (0.89-32.97) | .698 |
| IL-5 | 2.295 (0.11-16.44) | 2.47 (0.06-20.88) | .625 |
| IL-6 | 117.9 (8.49-1537.9) | 33.70 (1.75-6851) | .003 |
| IL-7 | 31.67 (4.91-613.2) | 12.10 (0.97-184.5) | .007 |
| IL-8 | 93.43 (19.42-8350) | 44.97 (8.81-37418) | .023 |
| IL-9 | 26.71 (2.46-130.8) | 21.89 (1.26-250.6) | .225 |
| IL-10 | 14.69 (5.36-260.5) | 11.62 (1.56-170.6) | .066 |
| IL-13 | 19.84 (1.01-123.0) | 8.980 (0.58-199.2) | .029 |
| Eotaxin | 176.7 (48.34-2265) | 148.4 (12.50-892.0) | .090 |
| PDGF-bb | 5610 (300.0-18523) | 4459 (61.75-18489) | .060 |
| Basic FGF | 60.79 (16.31-935.3) | 47.42 (6.77-254.3) | .079 |
| G-CSF | 65.73 (25.02-7232) | 55.71 (9.39-1770) | .078 |
| GM-CSF | 173.8 (47.04-851.1) | 132.0 (6.05-1836) | .081 |
| IFN-r | 93.31 (16.52-597.9) | 74.79 (10.22-6328) | .606 |
| IP-10 | 2011 (296.0-18554) | 1742 (70.84-18686) | .602 |
| MCP-1(MCAF) | 617.2 (86.33-4051) | 195.8 (31.28-10398) | .020 |
| MIP-1a | 7.710 (0.53-759.1) | 6.640 (0.71-565.6) | .460 |
| MIP-1b | 380.7 (121.7-4387) | 280.1 (59.98-50908) | .229 |
| TNF-a | 50.40 (21.43-362.8) | 40.81 (10.23-1029) | .216 |
| VEGF | 112.6 (12.17-1974) | 76.85 (8.27-4490) | .083 |
Bold indicates P < 0.05.
G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; MCAF, monocyte chemotactic and activating factor; MCP-1, monocyte chemoattractant protein-1; MIP, macrophage inflammatory protein; PDGF, platelet-derived growth factor; TNF-a, tumor necrosis factor-alpha; VEGF, vascular endothelial growth factor.
A high WBC count was defined as >100 × 109 cells per liter.
P value was evaluated using the Mann-Whitney U test, followed by the Benjamini-Hochberg method used as a correction for multiple testing.