Hematologic parameters from AA and SS mice after SPC-54 and TNF-α treatment
| Variable . | AA . | SS . | ||
|---|---|---|---|---|
| IgG (n = 3) . | IgG (n = 5) . | IgG/TNF (n = 10) . | SPC-54/TNF (n = 10) . | |
| RBC, 106/μL | 9.50 ± 0.072 | 6.57 ± 0.35∗ | 5.77 ± 0.15∗∗ | 5.62 ± 0.21∗∗ |
| Hematocrit, % | 34.2 ± 2.6 | 34.2 ± 2.55 | 30.56 ± 2.14 | 25.55 ± 1.55$ |
| PMN:lymph | 0.21 ± 0.04 | 0.17 ± 0.05 | 0.53 ± 0.18$ | 1.07 ± 0.12$ |
| WBC, 103/μL | 10.75 ± 1.28 | 31.3 ± 4.42∗ | 25.8 ± 3.59 | 28.21 ± 6.69 |
| PMN, 103/μL | 1. 57 ± 0.25 | 12.37 ± 2.34∗∗ | 28.77 ± 4.95$$ | 49.32 ± 2.36∗∗,$ |
| Lymphocyte, 103/μL | 75.85 ± 2.75 | 77.13 ± 6.52 | 66.23 ± 5.88 | 47.38 ± 2.55 |
| Monocyte, 103/μL | 4.8 ± 1.55 | 3.43 ± 1.68 | 3.8 ± 0.74 | 2.42 ± 0.25 |
| Platelet, 103/μL | 950 ± 82.5 | 919 ± 245 | 903 ± 320 | 268 ± 111.4∗∗,$$ |
| Variable . | AA . | SS . | ||
|---|---|---|---|---|
| IgG (n = 3) . | IgG (n = 5) . | IgG/TNF (n = 10) . | SPC-54/TNF (n = 10) . | |
| RBC, 106/μL | 9.50 ± 0.072 | 6.57 ± 0.35∗ | 5.77 ± 0.15∗∗ | 5.62 ± 0.21∗∗ |
| Hematocrit, % | 34.2 ± 2.6 | 34.2 ± 2.55 | 30.56 ± 2.14 | 25.55 ± 1.55$ |
| PMN:lymph | 0.21 ± 0.04 | 0.17 ± 0.05 | 0.53 ± 0.18$ | 1.07 ± 0.12$ |
| WBC, 103/μL | 10.75 ± 1.28 | 31.3 ± 4.42∗ | 25.8 ± 3.59 | 28.21 ± 6.69 |
| PMN, 103/μL | 1. 57 ± 0.25 | 12.37 ± 2.34∗∗ | 28.77 ± 4.95$$ | 49.32 ± 2.36∗∗,$ |
| Lymphocyte, 103/μL | 75.85 ± 2.75 | 77.13 ± 6.52 | 66.23 ± 5.88 | 47.38 ± 2.55 |
| Monocyte, 103/μL | 4.8 ± 1.55 | 3.43 ± 1.68 | 3.8 ± 0.74 | 2.42 ± 0.25 |
| Platelet, 103/μL | 950 ± 82.5 | 919 ± 245 | 903 ± 320 | 268 ± 111.4∗∗,$$ |
PMN, polymorphonuclear lymphocyte (neutrophil); WBC, total white blood cell count.
∗Indicates statistical difference compared with AA IgG (∗P < .05 and ∗∗P < .01).
$Indicates statistical difference compared with SS IgG ($P < .05; $$P < .01).