Multivariable analyses of EFS, CIR, and OS in childhood KMT2A-r AML
| . | pEFS . | pCIR . | pOS . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | HR . | 95% CI . | P value . | No. . | HR . | 95% CI . | P value . | No. . | HR . | 95% CI . | P value . | |
| Age at diagnosis, y | ||||||||||||
| ≤10 | 837 | 1.0 | 751 | 1.0 | 845 | 1.0 | ||||||
| >10 | 277 | 1.3 | 1.0-1.5 | .02 | 262 | 1.3 | 1.0-1.6 | .03 | 279 | 1.8 | 1.4-2.2 | <.01 |
| WBC count, ×109/L | ||||||||||||
| ≤100 | 865 | 1.0 | NA | 872 | 1.0 | |||||||
| >100 | 249 | 1.3 | 1.1-1.6 | <.01 | NA | NA | NA | NA | 252 | 1.5 | 1.2-1.8 | <.01 |
| Fusion-based group | ||||||||||||
| 9p22/KMT2A::MLLT3 | 479 | 1.0 | 440 | 1.0 | 484 | 1.0 | ||||||
| Xq24/KMT2A::SEPT6 | 21 | 0.5 | 0.2-1.1 | .08 | 21 | 0.5 | 0.2-1.3 | .14 | 21 | 0.3 | 0.1-1.4 | .13 |
| 1p32/KMT2A::EPS15 | 12 | 0.5 | 0.2-1.5 | .22 | 10 | 0.2 | 0.0-1.6 | .13 | 13 | 0.3 | 0.0-1.9 | .19 |
| 17q21 | 10 | 0.6 | 0.2-1.8 | .40 | 10 | 0.2 | 0.0-1.5 | .12 | 10 | 0.9 | 0.3-2.6 | .84 |
| 17q12 | 10 | 0.9 | 0.4-2.5 | .90 | 9 | 1.0 | 0.3-3.3 | .94 | 10 | 1.3 | 0.5-3.6 | .61 |
| 1q21/KMT2A::MLLT11 | 26 | 1.1 | 0.6-2.0 | .78 | 22 | 0.7 | 0.3-1.6 | .40 | 26 | 1.1 | 0.5-2.4 | .76 |
| 19p13.1/KMT2A::ELL | 67 | 1.3 | 0.9-1.9 | .13 | 58 | 1.3 | 0.8-2.0 | .24 | 67 | 1.1 | 0.7-1.8 | .65 |
| 19p13 | 14 | 1.1 | 0.5-2.3 | .85 | 19 | 1.3 | 0.6-2.6 | .51 | 14 | 1.4 | 0.6-3.3 | .38 |
| 19p13.3/KMT2A::MLLT1 | 52 | 1.6 | 1.1-2.3 | .01 | 49 | 1.8 | 1.2-2.8 | <.01 | 52 | 1.5 | 0.9-2.3 | .10 |
| 10p12/KMT2A::MLLT10 | 198 | 1.7 | 1.3-2.1 | <.01 | 178 | 1.7 | 1.3-2.2 | <.01 | 200 | 1.8 | 1.4-2.4 | <.01 |
| 4q21/KMT2A::AFF1 | 11 | 2.7 | 1.3-5.5 | <.01 | 6 | 1.6 | 0.5-5.1 | .40 | 11 | 4.5 | 2.2-9.4 | <.01 |
| 6q27/KMT2A::AFDN | 81 | 1.8 | 1.3-2.4 | <.01 | 74 | 2.0 | 1.4-2.8 | <.01 | 82 | 1.8 | 1.3-2.5 | <.01 |
| 10p11.2/KMT2A::ABI1 | 22 | 2.6 | 1.6-4.4 | <.01 | 22 | 3.0 | 1.7-5.2 | <.01 | 22 | 2.4 | 1.3-4.5 | <.01 |
| Other | 111 | 1.3 | 1.0-1.8 | .06 | 95 | 1.5 | 1.1-2.1 | .02 | 112 | 1.3 | 0.9-1.9 | .11 |
| Recurring ACAs | Yes/no | Yes/no | Yes/no | |||||||||
| Monosomy 10 | 13/1101 | 2.0 | 1.1-3.8 | .03 | 10/1003 | 2.1 | 1.0-4.5 | .04 | 13/1111 | 2.8 | 1.5-5.5 | <.01 |
| Trisomy 1 | NA | NA | NA | NA | NA | NA | NA | NA | 13/1111 | 3.9 | 2.0-7.4 | <.01 |
| Trisomy 4 | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ |
| Trisomy 6 | 60/1054 | 1.6 | 1.1-2.3 | .01 | 47/966 | 2.0 | 1.4-3.0 | <.01 | 60/1064 | 1.7 | 1.1-2.5 | .01 |
| Trisomy 8 | 194/920 | 0.8 | 0.6-1.0 | .05 | 172/841 | 0.7 | 0.5-1.0 | .03 | ∗ | ∗ | ∗ | ∗ |
| Trisomy 12 | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ |
| Trisomy 16 | 12/1102 | 2.5 | 1.3-4.8 | <.01 | 9/1004 | 4.5 | 2.1-9.5 | <.01 | NA | NA | NA | NA |
| Trisomy 17 | 8/1106 | 2.1 | 0.9-4.7 | .07 | ∗ | ∗ | ∗ | ∗ | 8/1116 | 2.2 | 0.9-5.1 | .08 |
| Trisomy X | 12/1102 | 2.2 | 1.1-4.3 | .03 | NA | NA | NA | NA | 12/1112 | 2.8 | 1.3-5.9 | <.01 |
| Add(12p) | 13/1101 | 2.2 | 1.2-3.9 | .01 | ∗ | ∗ | ∗ | ∗ | NA | NA | NA | NA |
| Del(9q) | 16/1098 | 2.0 | 1.1-3.5 | .03 | 14/999 | 2.2 | 1.1-4.5 | .02 | 16/1108 | 2.8 | 1.5-5.1 | <.01 |
| . | pEFS . | pCIR . | pOS . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | HR . | 95% CI . | P value . | No. . | HR . | 95% CI . | P value . | No. . | HR . | 95% CI . | P value . | |
| Age at diagnosis, y | ||||||||||||
| ≤10 | 837 | 1.0 | 751 | 1.0 | 845 | 1.0 | ||||||
| >10 | 277 | 1.3 | 1.0-1.5 | .02 | 262 | 1.3 | 1.0-1.6 | .03 | 279 | 1.8 | 1.4-2.2 | <.01 |
| WBC count, ×109/L | ||||||||||||
| ≤100 | 865 | 1.0 | NA | 872 | 1.0 | |||||||
| >100 | 249 | 1.3 | 1.1-1.6 | <.01 | NA | NA | NA | NA | 252 | 1.5 | 1.2-1.8 | <.01 |
| Fusion-based group | ||||||||||||
| 9p22/KMT2A::MLLT3 | 479 | 1.0 | 440 | 1.0 | 484 | 1.0 | ||||||
| Xq24/KMT2A::SEPT6 | 21 | 0.5 | 0.2-1.1 | .08 | 21 | 0.5 | 0.2-1.3 | .14 | 21 | 0.3 | 0.1-1.4 | .13 |
| 1p32/KMT2A::EPS15 | 12 | 0.5 | 0.2-1.5 | .22 | 10 | 0.2 | 0.0-1.6 | .13 | 13 | 0.3 | 0.0-1.9 | .19 |
| 17q21 | 10 | 0.6 | 0.2-1.8 | .40 | 10 | 0.2 | 0.0-1.5 | .12 | 10 | 0.9 | 0.3-2.6 | .84 |
| 17q12 | 10 | 0.9 | 0.4-2.5 | .90 | 9 | 1.0 | 0.3-3.3 | .94 | 10 | 1.3 | 0.5-3.6 | .61 |
| 1q21/KMT2A::MLLT11 | 26 | 1.1 | 0.6-2.0 | .78 | 22 | 0.7 | 0.3-1.6 | .40 | 26 | 1.1 | 0.5-2.4 | .76 |
| 19p13.1/KMT2A::ELL | 67 | 1.3 | 0.9-1.9 | .13 | 58 | 1.3 | 0.8-2.0 | .24 | 67 | 1.1 | 0.7-1.8 | .65 |
| 19p13 | 14 | 1.1 | 0.5-2.3 | .85 | 19 | 1.3 | 0.6-2.6 | .51 | 14 | 1.4 | 0.6-3.3 | .38 |
| 19p13.3/KMT2A::MLLT1 | 52 | 1.6 | 1.1-2.3 | .01 | 49 | 1.8 | 1.2-2.8 | <.01 | 52 | 1.5 | 0.9-2.3 | .10 |
| 10p12/KMT2A::MLLT10 | 198 | 1.7 | 1.3-2.1 | <.01 | 178 | 1.7 | 1.3-2.2 | <.01 | 200 | 1.8 | 1.4-2.4 | <.01 |
| 4q21/KMT2A::AFF1 | 11 | 2.7 | 1.3-5.5 | <.01 | 6 | 1.6 | 0.5-5.1 | .40 | 11 | 4.5 | 2.2-9.4 | <.01 |
| 6q27/KMT2A::AFDN | 81 | 1.8 | 1.3-2.4 | <.01 | 74 | 2.0 | 1.4-2.8 | <.01 | 82 | 1.8 | 1.3-2.5 | <.01 |
| 10p11.2/KMT2A::ABI1 | 22 | 2.6 | 1.6-4.4 | <.01 | 22 | 3.0 | 1.7-5.2 | <.01 | 22 | 2.4 | 1.3-4.5 | <.01 |
| Other | 111 | 1.3 | 1.0-1.8 | .06 | 95 | 1.5 | 1.1-2.1 | .02 | 112 | 1.3 | 0.9-1.9 | .11 |
| Recurring ACAs | Yes/no | Yes/no | Yes/no | |||||||||
| Monosomy 10 | 13/1101 | 2.0 | 1.1-3.8 | .03 | 10/1003 | 2.1 | 1.0-4.5 | .04 | 13/1111 | 2.8 | 1.5-5.5 | <.01 |
| Trisomy 1 | NA | NA | NA | NA | NA | NA | NA | NA | 13/1111 | 3.9 | 2.0-7.4 | <.01 |
| Trisomy 4 | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ |
| Trisomy 6 | 60/1054 | 1.6 | 1.1-2.3 | .01 | 47/966 | 2.0 | 1.4-3.0 | <.01 | 60/1064 | 1.7 | 1.1-2.5 | .01 |
| Trisomy 8 | 194/920 | 0.8 | 0.6-1.0 | .05 | 172/841 | 0.7 | 0.5-1.0 | .03 | ∗ | ∗ | ∗ | ∗ |
| Trisomy 12 | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ | ∗ |
| Trisomy 16 | 12/1102 | 2.5 | 1.3-4.8 | <.01 | 9/1004 | 4.5 | 2.1-9.5 | <.01 | NA | NA | NA | NA |
| Trisomy 17 | 8/1106 | 2.1 | 0.9-4.7 | .07 | ∗ | ∗ | ∗ | ∗ | 8/1116 | 2.2 | 0.9-5.1 | .08 |
| Trisomy X | 12/1102 | 2.2 | 1.1-4.3 | .03 | NA | NA | NA | NA | 12/1112 | 2.8 | 1.3-5.9 | <.01 |
| Add(12p) | 13/1101 | 2.2 | 1.2-3.9 | .01 | ∗ | ∗ | ∗ | ∗ | NA | NA | NA | NA |
| Del(9q) | 16/1098 | 2.0 | 1.1-3.5 | .03 | 14/999 | 2.2 | 1.1-4.5 | .02 | 16/1108 | 2.8 | 1.5-5.1 | <.01 |
Values in boldface indicate statistical significance. ACA type was excluded from multivariable analyses, as the specific ACAs and the ACA type variables are related. 9p22/KMT2A::MLLT3 refers to t(9;11)(p22;q23), 10p12/KMT2A::MLLT10 to t(10;11)(p12;q23), 6q27/KMT2A::AFDN to t(6;11)(q27;q23), 19p13 to t(11;19)(q23;p13) without ascertained subband, 19p13.1/KMT2A::ELL to t(11;19)(q23;p13.1), 19p13.3/KMT2A::MLLT1 to t(11;19)(q23;p13.3), 1q21/KMT2A::MLLT11 to t(1;11)(q21;q23), 10p11.2/KMT2A::ABI1 to t(10;11)(p11.2;q23), Xq24/KMT2A::SEPT6 to t(X;11)(q24;q23), 17q21 to t(11;17)(q23;q21), 4q21/KMT2A::AFF1 to t(4;11)(q21;q23), 1p32/KMT2A::EPS15 to t(1;11)(p32;q23), and 17q12 to t(11;17)(q23;q12).
NA, not applied (not significant variables in univariable Cox regression analyses, see supplemental Table 5); abbreviations are explained in Table 1.
Omitted from the final multivariable model of EFS/CIR/OS because of a P-value > .10 in stepwise backward elimination.