Overlapping integration clusters in 2 canine AAV-cFVIII studies after long-term follow-up
| Chr . | UNC integration clusters . | Queen’s TES CIS . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Hits . | Start . | End . | Width . | Gene∗ . | CIS (no. of events) . | Mean locus . | Width . | Gene∗ . | |
| 4 | 7 | 14530145 | 14924592 | 39 448 | EGR2 | 7 (26) | 14746173 | 72 601 | MIR1296 |
| 4 | 26 | 39589684 | 39589877 | 194 | DUSP1 | nr | nr | nr | nr |
| 13 | 5 | 62155847 | 62632404 | 476 558 | ALB | 6 (30) | 62161330 | 16 400 | ALB |
| 18 | 14 | 48484014 | 48821243 | 337 230 | CCND1 | 26 (7) | 48641914 | 60 162 | CCND1 |
| 25 | 15 | 34458017 | 34601125 | 143 109 | EGR3 | 12 (14) | 34589168 | 7 314 | MIR320 |
| Chr . | UNC integration clusters . | Queen’s TES CIS . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Hits . | Start . | End . | Width . | Gene∗ . | CIS (no. of events) . | Mean locus . | Width . | Gene∗ . | |
| 4 | 7 | 14530145 | 14924592 | 39 448 | EGR2 | 7 (26) | 14746173 | 72 601 | MIR1296 |
| 4 | 26 | 39589684 | 39589877 | 194 | DUSP1 | nr | nr | nr | nr |
| 13 | 5 | 62155847 | 62632404 | 476 558 | ALB | 6 (30) | 62161330 | 16 400 | ALB |
| 18 | 14 | 48484014 | 48821243 | 337 230 | CCND1 | 26 (7) | 48641914 | 60 162 | CCND1 |
| 25 | 15 | 34458017 | 34601125 | 143 109 | EGR3 | 12 (14) | 34589168 | 7 314 | MIR320 |
Comparison of CIS occurring in this study to those reported by Nguyen et al.8
Chr, chromosome; Hits, number of calls against 50 random sites; nr, not represented in TES CIS data set; UNC, University of North Carolina.
Differences in gene annotations are noted in these 2 analyses.