Table 2. Multivariable Cox analysis of... | American Society of Hematology

Table 2.

Multivariable Cox analysis of the prognostic impact of KISS and other clinically relevant variables

Variable	OS				LFS
Variable	HR	95% CI lower	95% CI upper	P value	HR	95% CI lower	95% CI upper	P value
Age∗	1.032	1.019	1.045	<.001	1.020	1.009	1.031	.001
IPSS-R†	1.603	1.341	1.916	<.001	1.502	1.266	1.783	< .001
Mutation
ASXL1	0.819	0.510	1.316	.409	0.811	0.516	1.274	.363
EZH2	2.754	1.450	5.233	.002	1.835	0.977	3.447	.059
RUNX1	1.066	0.692	1.641	.772	1.036	0.679	1.581	.870
SF3B1	0.561	0.302	1.041	.067	0.560	0.311	1.010	.054
SRSF2	1.084	0.632	1.861	.769	1.294	0.778	2.150	.321
STAG2	1.139	0.682	1.903	.619	1.380	0.847	2.247	.196
TET2	1.646	1.033	2.623	.036	1.518	0.975	2.362	.065
TP53	4.007	2.428	6.613	<.001	2.144	1.349	3.408	.001
KISS∗	1.692	1.151	2.488	.008	1.797	1.238	2.608	.002

Variable	OS				LFS
Variable	HR	95% CI lower	95% CI upper	P value	HR	95% CI lower	95% CI upper	P value
Age∗	1.032	1.019	1.045	<.001	1.020	1.009	1.031	.001
IPSS-R†	1.603	1.341	1.916	<.001	1.502	1.266	1.783	< .001
Mutation
ASXL1	0.819	0.510	1.316	.409	0.811	0.516	1.274	.363
EZH2	2.754	1.450	5.233	.002	1.835	0.977	3.447	.059
RUNX1	1.066	0.692	1.641	.772	1.036	0.679	1.581	.870
SF3B1	0.561	0.302	1.041	.067	0.560	0.311	1.010	.054
SRSF2	1.084	0.632	1.861	.769	1.294	0.778	2.150	.321
STAG2	1.139	0.682	1.903	.619	1.380	0.847	2.247	.196
TET2	1.646	1.033	2.623	.036	1.518	0.975	2.362	.065
TP53	4.007	2.428	6.613	<.001	2.144	1.349	3.408	.001
KISS∗	1.692	1.151	2.488	.008	1.797	1.238	2.608	.002

CI, confidence interval.

As continuous variable.

IPSS-R risk groups: very low, low, intermediate, high, and very high.