Clinical and laboratory characteristics according to the KISS strata
| Variable . | KISS-high (n = 173) . | KISS-low (n = 109) . | P value . |
|---|---|---|---|
| Sex, n (%) | .434 | ||
| Female | 59 (34.1) | 43 (39.4) | |
| Male | 114 (65.9) | 66 (60.6) | |
| Age, median (range) | 72.1 (17.8-94.2) | 67.6 (20.0-94.2) | .020 |
| Laboratory data, median (range) | |||
| WBC, × 109/L | 3.8 (0.3-56.3) | 4.3 (0.8-25.5) | .311 |
| Hb, g/dL | 8.4 (3.5-15.3) | 8.2 (4.2-16.9) | .535 |
| Platelet, × 109/L | 75 (1-721) | 111 (3-405) | .003 |
| PB blast, % | 1.0 (0-18.0) | 0 (0-4.0) | <.001 |
| BM blast, % | 9.2 (0-19.0) | 2 (0-17.8) | <.001 |
| 2016 WHO classification, n (%) | |||
| MDS-SLD | 5 (2.9) | 26 (23.9) | <.001 |
| MDS-MLD | 19 (11.0) | 37 (33.9) | <.001 |
| MDS-RS-SLD | 2 (1.2) | 17 (15.6) | <.001 |
| MDS-RS-MLD | 4 (2.3) | 11 (10.1) | .010 |
| MDS-del(5q) | 1 (0.6) | 1 (0.9) | >.999 |
| MDS-EB1 | 55 (31.8) | 7 (6.4) | <.001 |
| MDS-EB2 | 83 (48.0) | 9 (8.3) | <.001 |
| MDS-U | 4 (2.3) | 1 (0.9) | .689 |
| IPSS-R, n (%) | |||
| Very low | 3 (1.8) | 10 (9.7) | .007 |
| Low | 21 (12.4) | 53 (51.5) | <.001 |
| Int | 32 (18.8) | 29 (28.2) | .1 |
| High | 57 (33.5) | 8 (7.8) | <.001 |
| Very high | 57 (33.5) | 3 (2.9) | <.001 |
| Karyotype, n (%) | |||
| Normal karyotype | 84 (49.4) | 78 (75.7) | <.001 |
| Complex karyotype | 35 (20.6) | 1 (1.0) | <.001 |
| Variable . | KISS-high (n = 173) . | KISS-low (n = 109) . | P value . |
|---|---|---|---|
| Sex, n (%) | .434 | ||
| Female | 59 (34.1) | 43 (39.4) | |
| Male | 114 (65.9) | 66 (60.6) | |
| Age, median (range) | 72.1 (17.8-94.2) | 67.6 (20.0-94.2) | .020 |
| Laboratory data, median (range) | |||
| WBC, × 109/L | 3.8 (0.3-56.3) | 4.3 (0.8-25.5) | .311 |
| Hb, g/dL | 8.4 (3.5-15.3) | 8.2 (4.2-16.9) | .535 |
| Platelet, × 109/L | 75 (1-721) | 111 (3-405) | .003 |
| PB blast, % | 1.0 (0-18.0) | 0 (0-4.0) | <.001 |
| BM blast, % | 9.2 (0-19.0) | 2 (0-17.8) | <.001 |
| 2016 WHO classification, n (%) | |||
| MDS-SLD | 5 (2.9) | 26 (23.9) | <.001 |
| MDS-MLD | 19 (11.0) | 37 (33.9) | <.001 |
| MDS-RS-SLD | 2 (1.2) | 17 (15.6) | <.001 |
| MDS-RS-MLD | 4 (2.3) | 11 (10.1) | .010 |
| MDS-del(5q) | 1 (0.6) | 1 (0.9) | >.999 |
| MDS-EB1 | 55 (31.8) | 7 (6.4) | <.001 |
| MDS-EB2 | 83 (48.0) | 9 (8.3) | <.001 |
| MDS-U | 4 (2.3) | 1 (0.9) | .689 |
| IPSS-R, n (%) | |||
| Very low | 3 (1.8) | 10 (9.7) | .007 |
| Low | 21 (12.4) | 53 (51.5) | <.001 |
| Int | 32 (18.8) | 29 (28.2) | .1 |
| High | 57 (33.5) | 8 (7.8) | <.001 |
| Very high | 57 (33.5) | 3 (2.9) | <.001 |
| Karyotype, n (%) | |||
| Normal karyotype | 84 (49.4) | 78 (75.7) | <.001 |
| Complex karyotype | 35 (20.6) | 1 (1.0) | <.001 |
Hb, hemoglobin; Int, intermediate; MDS-RS-SLD, MDS with ring sideroblasts and single-lineage dysplasia; MDS-RS-MLD, MDS with ring sideroblasts and multilineage dysplasia; MDS-U, MDS, unclassifiable.