Univariate and multivariate Cox or Fine-gray analysis for the impact of mutations in AS and MTF on the treatment outcomes with respect to MMR, MR2, MR4, FFS, progression, and OS after TKI therapy in patients with CML
| . | Univariate . | Multivariate, enter . | Multivariate, stepwise . | |||
|---|---|---|---|---|---|---|
| P value . | HR . | P value . | HR . | P value . | HR . | |
| MR2 | ||||||
| Mutation | .043 | 0.485 (0.241-0.976) | .04 | 0.449 (0.210-0.963) | .039 | 0.449 (0.210-0.960) |
| ACA | .0015 | 0.478 (0.304-0.754) | .024 | 0.603 (0.390-0.934) | .0025 | 0.522 (0.342-0.795) |
| Disease phase | .00011 | 0.307 (0.169-0.560) | .12 | 0.603 (0.318-1.14) | - | |
| TKI type | .0000019 | 2.34 (1.65-3.33) | .003 | 1.81 (1.23-2.68) | .0026 | 1.82 (1.23-2.68) |
| MMR | ||||||
| Mutation | .0047 | 0.364 (0.180-0.733) | .023 | 0.416 (0.195-0.888) | .03 | 0.421 (0.193-0.919) |
| ACA | .0021 | 0.484 (0.304-0.769) | .068 | 0.654 (0.414-1.03) | - | |
| Disease phase | .000052 | 0.274 (0.146-0.513) | .02 | 0.440 (0.220-0.881) | .002 | 0.341 (0.172-0.674) |
| TKI type | .000056 | 1.97 (1.42-2.74) | .045 | 1.46 (1.01-2.12) | .021 | 1.53 (1.07-2.19) |
| MR4 | ||||||
| Mutation | .012 | 0.403 (0.198-0.819) | .024 | 0.447 (0.222-0.900) | .018 | 0.429 (0.212-0.866) |
| ACA | .016 | 0.516 (0.302-0.882) | .061 | 0.575 (0.322-1.03) | .017 | 0.522 (0.306-0.889) |
| Disease phase | .0052 | 0.367 (0.181-0.741) | .44 | 0.736 (0.340-1.60) | - | |
| TKI type | .026 | 1.46 (1.05-2.02) | .77 | 1.06 (0.734-1.52) | - | |
| FFS | ||||||
| Mutation | .00261 | 2.77 (1.43-5.39) | .0239 | 2.53 (1.13-5.66) | .0238 | 2.53 (1.13-5.66) |
| ACA | .278 | 1.43 (0.749-2.74) | .984 | 0.993 (0.493-2.00) | - | |
| Disease phase | .00000321 | 3.99 (2.23-7.13) | .00279 | 3.34 (1.51-7.35) | .00132 | 3.33 (1.60-6.92) |
| TKI type | .00163 | 0.309 (0.149-0.641) | .00675 | 0.334 (0.151-0.738) | .00675 | 0.334 (0.151-0.738) |
| Progression | ||||||
| Mutation | .012 | 2.481 (1.221-5.050) | .27 | 2.049 (0.571-7.407) | - | |
| ACA | .016 | 0.516 (0.302-0.882) | .021 | 3.05 (1.19-7.85) | .035 | 2.79 (1.07-7.24) |
| Disease phase | .0052 | 0.367 (0.181-0.741) | .000012 | 7.17 (2.97-17.3) | .0000087 | 8.13 (3.23-20.5) |
| TKI type | .026 | 1.46 (1.05-2.02) | .20 | 0.261 (0.0342-2.00) | - | |
| OS | ||||||
| Mutation | .0204 | 2.42 (1.15-5.11) | .235 | 1.78 (0.689-4.58) | - | |
| ACA | .0865 | 1.87 (0.914-3.83) | .434 | 1.36 (0.630-2.94) | - | |
| Disease phase | .0000508 | 3.73 (1.97-7.06) | .0211 | 2.82 (1.17-6.79) | .00424 | 3.30 (1.46-7.47) |
| TKI type | .00557 | 0.237 (0.0856-0.656) | .0076 | 0.143 (0.0343-0.597) | .00648 | 0.138 (0.0332-0.574) |
| . | Univariate . | Multivariate, enter . | Multivariate, stepwise . | |||
|---|---|---|---|---|---|---|
| P value . | HR . | P value . | HR . | P value . | HR . | |
| MR2 | ||||||
| Mutation | .043 | 0.485 (0.241-0.976) | .04 | 0.449 (0.210-0.963) | .039 | 0.449 (0.210-0.960) |
| ACA | .0015 | 0.478 (0.304-0.754) | .024 | 0.603 (0.390-0.934) | .0025 | 0.522 (0.342-0.795) |
| Disease phase | .00011 | 0.307 (0.169-0.560) | .12 | 0.603 (0.318-1.14) | - | |
| TKI type | .0000019 | 2.34 (1.65-3.33) | .003 | 1.81 (1.23-2.68) | .0026 | 1.82 (1.23-2.68) |
| MMR | ||||||
| Mutation | .0047 | 0.364 (0.180-0.733) | .023 | 0.416 (0.195-0.888) | .03 | 0.421 (0.193-0.919) |
| ACA | .0021 | 0.484 (0.304-0.769) | .068 | 0.654 (0.414-1.03) | - | |
| Disease phase | .000052 | 0.274 (0.146-0.513) | .02 | 0.440 (0.220-0.881) | .002 | 0.341 (0.172-0.674) |
| TKI type | .000056 | 1.97 (1.42-2.74) | .045 | 1.46 (1.01-2.12) | .021 | 1.53 (1.07-2.19) |
| MR4 | ||||||
| Mutation | .012 | 0.403 (0.198-0.819) | .024 | 0.447 (0.222-0.900) | .018 | 0.429 (0.212-0.866) |
| ACA | .016 | 0.516 (0.302-0.882) | .061 | 0.575 (0.322-1.03) | .017 | 0.522 (0.306-0.889) |
| Disease phase | .0052 | 0.367 (0.181-0.741) | .44 | 0.736 (0.340-1.60) | - | |
| TKI type | .026 | 1.46 (1.05-2.02) | .77 | 1.06 (0.734-1.52) | - | |
| FFS | ||||||
| Mutation | .00261 | 2.77 (1.43-5.39) | .0239 | 2.53 (1.13-5.66) | .0238 | 2.53 (1.13-5.66) |
| ACA | .278 | 1.43 (0.749-2.74) | .984 | 0.993 (0.493-2.00) | - | |
| Disease phase | .00000321 | 3.99 (2.23-7.13) | .00279 | 3.34 (1.51-7.35) | .00132 | 3.33 (1.60-6.92) |
| TKI type | .00163 | 0.309 (0.149-0.641) | .00675 | 0.334 (0.151-0.738) | .00675 | 0.334 (0.151-0.738) |
| Progression | ||||||
| Mutation | .012 | 2.481 (1.221-5.050) | .27 | 2.049 (0.571-7.407) | - | |
| ACA | .016 | 0.516 (0.302-0.882) | .021 | 3.05 (1.19-7.85) | .035 | 2.79 (1.07-7.24) |
| Disease phase | .0052 | 0.367 (0.181-0.741) | .000012 | 7.17 (2.97-17.3) | .0000087 | 8.13 (3.23-20.5) |
| TKI type | .026 | 1.46 (1.05-2.02) | .20 | 0.261 (0.0342-2.00) | - | |
| OS | ||||||
| Mutation | .0204 | 2.42 (1.15-5.11) | .235 | 1.78 (0.689-4.58) | - | |
| ACA | .0865 | 1.87 (0.914-3.83) | .434 | 1.36 (0.630-2.94) | - | |
| Disease phase | .0000508 | 3.73 (1.97-7.06) | .0211 | 2.82 (1.17-6.79) | .00424 | 3.30 (1.46-7.47) |
| TKI type | .00557 | 0.237 (0.0856-0.656) | .0076 | 0.143 (0.0343-0.597) | .00648 | 0.138 (0.0332-0.574) |
Overall, samples from 254 patients were analyzed.