Table 2. Univariate and multivariate... | American Society of Hematology

Table 2.

Univariate and multivariate logistic regression analysis for the impact of somatic mutations between progression/treatment failure group vs optimal responder to TKI therapy in overall population of 254 patients with CML

Any mutation	Univariate		Multivariate, enter		Multivariate, stepwise
Any mutation	P value	OR	P value	OR	P value	OR
Any mutation∗
Mutation∗	.00503	2.36 (1.30-4.32)	.00861	2.78 (1.300-5.970)	.0173	2.36 (1.160-4.800)
ACA	.0898	1.95 (0.901-4.23)	.416	1.57 (0.526-4.717)	-
Disease phase	.983	1.03 × 10⁸ (0.000-Inf)	.985	1.67 × 10⁸ (0.000-Inf)	-
TKI type	.00214	0.339 (0.170-0.676)	.0101	0.328 (0.141-0.767)	.00508	0.333 (0.154-0.718)
Mutation in epigenetic modification pathway†
Mutation†	.535	1.25 (0.616-2.54)	.541	1.34 (0.527-3.390)	-
ACA	.0898	1.95 (0.901-4.23)	.544	1.40 (0.476-4.10)	-
Disease phase	.983	1.03 × 10⁸ (0.000-Inf)	.986	1.43 × 10⁸ (0.000-Inf)	-
TKI type	.00214	0.339 (0.170-0.676)	.012	0.344 (0.150-0.791)	.00576	0.343 (0.161-0.733)
Mutation in AS and MTF‡
Mutation‡	.0235	3.35 (1.18-9.56)	.0646	3.70 (0.924-14.8)	.0345	4.04 (1.11-14.7)
ACA	.0898	1.95 (0.901-4.23)	.598	1.34 (0.455-3.92)	—
Disease phase	.983	1.03 × 10⁸ (0.000-Inf)	.986	1.29 × 10⁸ (0.000-Inf)	—
TKI type	.00214	0.339 (0.170-0.676)	.014	0.349 (0.151-0.808)	.00754	0.352 (0.164-0.757)

Any mutation	Univariate		Multivariate, enter		Multivariate, stepwise
Any mutation	P value	OR	P value	OR	P value	OR
Any mutation∗
Mutation∗	.00503	2.36 (1.30-4.32)	.00861	2.78 (1.300-5.970)	.0173	2.36 (1.160-4.800)
ACA	.0898	1.95 (0.901-4.23)	.416	1.57 (0.526-4.717)	-
Disease phase	.983	1.03 × 10⁸ (0.000-Inf)	.985	1.67 × 10⁸ (0.000-Inf)	-
TKI type	.00214	0.339 (0.170-0.676)	.0101	0.328 (0.141-0.767)	.00508	0.333 (0.154-0.718)
Mutation in epigenetic modification pathway†
Mutation†	.535	1.25 (0.616-2.54)	.541	1.34 (0.527-3.390)	-
ACA	.0898	1.95 (0.901-4.23)	.544	1.40 (0.476-4.10)	-
Disease phase	.983	1.03 × 10⁸ (0.000-Inf)	.986	1.43 × 10⁸ (0.000-Inf)	-
TKI type	.00214	0.339 (0.170-0.676)	.012	0.344 (0.150-0.791)	.00576	0.343 (0.161-0.733)
Mutation in AS and MTF‡
Mutation‡	.0235	3.35 (1.18-9.56)	.0646	3.70 (0.924-14.8)	.0345	4.04 (1.11-14.7)
ACA	.0898	1.95 (0.901-4.23)	.598	1.34 (0.455-3.92)	—
Disease phase	.983	1.03 × 10⁸ (0.000-Inf)	.986	1.29 × 10⁸ (0.000-Inf)	—
TKI type	.00214	0.339 (0.170-0.676)	.014	0.349 (0.151-0.808)	.00754	0.352 (0.164-0.757)

Inf, infinite.

∗

Any mutation.

†

Mutation in epigenetic modification pathway.

‡

Mutation in AS and myeloid transcription factor.

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