Relative changes in cerebral hemodynamic markers on voxelotor
| . | Wk 4 . | Wk 8 . | Wk 12 . |
|---|---|---|---|
| rOEF, % | −11.5 (−17.9 to −5.1)∗ | −13.6 (−21.4 to −5.7)∗ | −12.9 (−18.1 to −7.8)∗ |
| rCBFi, % | −29.9 (−52.7 to −7.1)† | −32.8 (−40.8 to −24.8)‡ | −24.1 (−40.0 to −8.2)† |
| rCBV, % | 0.9 (−10.1 to 11.0) | 4.4 (−6.2 to 15.0) | 3.8 (−2.8 to 10.4) |
| . | Wk 4 . | Wk 8 . | Wk 12 . |
|---|---|---|---|
| rOEF, % | −11.5 (−17.9 to −5.1)∗ | −13.6 (−21.4 to −5.7)∗ | −12.9 (−18.1 to −7.8)∗ |
| rCBFi, % | −29.9 (−52.7 to −7.1)† | −32.8 (−40.8 to −24.8)‡ | −24.1 (−40.0 to −8.2)† |
| rCBV, % | 0.9 (−10.1 to 11.0) | 4.4 (−6.2 to 15.0) | 3.8 (−2.8 to 10.4) |
Data are reported as median (IQR). P values were obtained from a 2-sided paired Wilcoxon signed-rank test.
rCBFi, relative changes in CBFi from pretreatment levels at wk 4, 8, and 12; rCBV, relative changes in CBV from pretreatment levels at wk 4, 8, and 12; rOEF, relative changes in OEF levels from pretreatment levels at wk 4, 8, and 12.
P < .05.
P < .01.
P < .005.