Table 3.

Relative changes in cerebral hemodynamic markers on voxelotor

Wk 4Wk 8Wk 12
rOEF, % −11.5 (−17.9 to −5.1)  −13.6 (−21.4 to −5.7)  −12.9 (−18.1 to −7.8)  
rCBFi, % −29.9 (−52.7 to −7.1)  −32.8 (−40.8 to −24.8)  −24.1 (−40.0 to −8.2)  
rCBV, % 0.9 (−10.1 to 11.0) 4.4 (−6.2 to 15.0) 3.8 (−2.8 to 10.4) 
Wk 4Wk 8Wk 12
rOEF, % −11.5 (−17.9 to −5.1)  −13.6 (−21.4 to −5.7)  −12.9 (−18.1 to −7.8)  
rCBFi, % −29.9 (−52.7 to −7.1)  −32.8 (−40.8 to −24.8)  −24.1 (−40.0 to −8.2)  
rCBV, % 0.9 (−10.1 to 11.0) 4.4 (−6.2 to 15.0) 3.8 (−2.8 to 10.4) 

Data are reported as median (IQR). P values were obtained from a 2-sided paired Wilcoxon signed-rank test.

rCBFi, relative changes in CBFi from pretreatment levels at wk 4, 8, and 12; rCBV, relative changes in CBV from pretreatment levels at wk 4, 8, and 12; rOEF, relative changes in OEF levels from pretreatment levels at wk 4, 8, and 12.

P < .05.

P < .01.

P < .005.

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