Kinetic parameters for binding of CD33/CD123 NANOBODY TCE to human and cynomolgous target proteins
| Antigen . | Human . | Cynomolgus monkey . | ||||
|---|---|---|---|---|---|---|
| kon (1/Ms) . | koff (1/s) . | KD(M) . | kon (1/Ms) . | koff (1/s) . | KD(M) . | |
| CD33-Fc | 3.5E+05 | 2.7E−03 | 7.6E−09 | 2.8E+05 | 1.9E−03 | 6.9E−09 |
| CD123-Fc | 1.3E+06 | 7.4E−04 | 5.9E−10 | 1.2E+06 | 2.4E−03 | 2.0E−09 |
| Albumin | 2.2E+05 | 2.1E−03 | 9.7E−09 | 2.5E+05 | 2.0E−03 | 7.9E−09 |
| Antigen . | Human . | Cynomolgus monkey . | ||||
|---|---|---|---|---|---|---|
| kon (1/Ms) . | koff (1/s) . | KD(M) . | kon (1/Ms) . | koff (1/s) . | KD(M) . | |
| CD33-Fc | 3.5E+05 | 2.7E−03 | 7.6E−09 | 2.8E+05 | 1.9E−03 | 6.9E−09 |
| CD123-Fc | 1.3E+06 | 7.4E−04 | 5.9E−10 | 1.2E+06 | 2.4E−03 | 2.0E−09 |
| Albumin | 2.2E+05 | 2.1E−03 | 9.7E−09 | 2.5E+05 | 2.0E−03 | 7.9E−09 |