Development of humanized mouse model with controllable numbers of NK cells and T cells in TME
| Group . | Description . | Cells in inoculum . | Cells in tumor FNA 17-18 d after tumor inoculation . | ||
|---|---|---|---|---|---|
| PBMCs . | Raji . | % T cells∗ . | % NK cells∗ . | ||
| 1 | No PBMCs | — | 1 × 106 | 0 ± 0 | 0 ± 0 |
| 2 | Locally injected PBMCs-Raji mixed at time of inoculation | 1 × 105 | 1 × 106 | 8.7 ± 0.1 | 1.5 ± 0.6 |
| 3 | Locally injected PBMCs-Raji mixed at time of inoculation | 5 × 105 | 1 × 106 | 24.4 ± 15.2 | 4.4 ± 2.5 |
| 4 | Systemically injected PBMCs 10 d before Raji inoculation | 1 × 107 | 1 × 106 | 25.2 ± 6.9 | 0.4 ± 0.3 |
| 5 | Systemically injected PBMCs 12 d after Raji inoculation | 1 × 107 | 1 × 106 | 14.6 ± 11 | 1 ± 0.1 |
| Group . | Description . | Cells in inoculum . | Cells in tumor FNA 17-18 d after tumor inoculation . | ||
|---|---|---|---|---|---|
| PBMCs . | Raji . | % T cells∗ . | % NK cells∗ . | ||
| 1 | No PBMCs | — | 1 × 106 | 0 ± 0 | 0 ± 0 |
| 2 | Locally injected PBMCs-Raji mixed at time of inoculation | 1 × 105 | 1 × 106 | 8.7 ± 0.1 | 1.5 ± 0.6 |
| 3 | Locally injected PBMCs-Raji mixed at time of inoculation | 5 × 105 | 1 × 106 | 24.4 ± 15.2 | 4.4 ± 2.5 |
| 4 | Systemically injected PBMCs 10 d before Raji inoculation | 1 × 107 | 1 × 106 | 25.2 ± 6.9 | 0.4 ± 0.3 |
| 5 | Systemically injected PBMCs 12 d after Raji inoculation | 1 × 107 | 1 × 106 | 14.6 ± 11 | 1 ± 0.1 |
Mean ± standard deviation.