Index variants at novel loci discovered in the cross-population, population-specific, and multiphenotype analyses
| rsID . | Chr:pos . | Gene . | Alleles . | FVIII levels . | VWF levels . | Multiphenotype . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Freq, % . | Beta . | SE . | P value . | Freq, % . | Beta . | SE . | P value . | P value . | ||||
| FVIII levels (cross-population) | ||||||||||||
| rs75077631 | 5:177413083 | GRK6/F12 | G/GC | 37.2 | −2.56 | 0.36 | 1.8E−12 | 31.2 | −0.44 | 0.40 | 2.8E−01 | 6.0E−13 |
| rs62061426 | 17:7170806 | ASGR1 | A/G | 18.8 | 2.42 | 0.38 | 1.3E−10 | 19.0 | 1.37 | 0.41 | 7.9E−04 | 1.4E−09 |
| rs710446 | 3:186742138 | KNG1 | T/C | 57.0 | −1.85 | 0.29 | 1.4E−10 | 57.7 | −0.55 | 0.32 | 8.1E−02 | 9.1E−10 |
| rs6727115 | 2:62389406 | B3GNT2 | T/C | 76.4 | −2.13 | 0.35 | 1.3E−09 | 78.0 | −2.00 | 0.39 | 2.4E−07 | 6.9E−11 |
| rs35257264 | 11:126426921 | ST3GAL4/KIRREL3 | T/C | 2.2 | 7.45 | 0.98 | 2.5E−14 | 2.4 | 6.67 | 1.07 | 3.7E−10 | 8.1E−16 |
| rs868875 | 19:7766280 | CLEC4M | A/G | 72.0 | 2.10 | 0.32 | 6.0E−11 | 70.9 | 2.36 | 0.35 | 1.7E−11 | 2.3E−15 |
| FVIII levels (White participants) | ||||||||||||
| rs35206772 | 6:41325017 | TREM1/NCR2 | A/G | 67.6 | −2.02 | 0.33 | 9.3E−10 | 67.8 | −0.72 | 0.43 | 9.0E−02 | 2.3E−07 |
| VWF levels (White participants) | ||||||||||||
| rs61558368 | 2:62414160 | B3GNT2 | T/C | 34.9 | 1.24 | 0.33 | 1.9E−04 | 35.6 | 2.09 | 0.35 | 2.0E−09 | 1.2E−08 |
| Multiphenotype analysis of FVIII levels and VWF levels (cross-population) | ||||||||||||
| rs12979891 | 19:48723999 | RASIP1/FUT1/FUT2 | T/C | 44.2 | 1.37 | 0.30 | 3.9E−06 | 49.0 | 1.83 | 0.32 | 1.8E−08 | 2.6E−09 |
| rs145633869 | 15:43719006 | CKMT1A/PDIA3 | CAGAG/C | 98.3 | 6.55 | 1.22 | 8.0E−08 | 98.1 | 6.15 | 1.26 | 1.1E−06 | 4.1E−09 |
| rs184336448 | 2:198846960 | PLCL1/SATB2 | A/T | 0.43 | 11.01 | 2.53 | 1.3E−05 | 0.53 | 14.61 | 2.59 | 1.6E−08 | 4.4E−09 |
| rsID . | Chr:pos . | Gene . | Alleles . | FVIII levels . | VWF levels . | Multiphenotype . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Freq, % . | Beta . | SE . | P value . | Freq, % . | Beta . | SE . | P value . | P value . | ||||
| FVIII levels (cross-population) | ||||||||||||
| rs75077631 | 5:177413083 | GRK6/F12 | G/GC | 37.2 | −2.56 | 0.36 | 1.8E−12 | 31.2 | −0.44 | 0.40 | 2.8E−01 | 6.0E−13 |
| rs62061426 | 17:7170806 | ASGR1 | A/G | 18.8 | 2.42 | 0.38 | 1.3E−10 | 19.0 | 1.37 | 0.41 | 7.9E−04 | 1.4E−09 |
| rs710446 | 3:186742138 | KNG1 | T/C | 57.0 | −1.85 | 0.29 | 1.4E−10 | 57.7 | −0.55 | 0.32 | 8.1E−02 | 9.1E−10 |
| rs6727115 | 2:62389406 | B3GNT2 | T/C | 76.4 | −2.13 | 0.35 | 1.3E−09 | 78.0 | −2.00 | 0.39 | 2.4E−07 | 6.9E−11 |
| rs35257264 | 11:126426921 | ST3GAL4/KIRREL3 | T/C | 2.2 | 7.45 | 0.98 | 2.5E−14 | 2.4 | 6.67 | 1.07 | 3.7E−10 | 8.1E−16 |
| rs868875 | 19:7766280 | CLEC4M | A/G | 72.0 | 2.10 | 0.32 | 6.0E−11 | 70.9 | 2.36 | 0.35 | 1.7E−11 | 2.3E−15 |
| FVIII levels (White participants) | ||||||||||||
| rs35206772 | 6:41325017 | TREM1/NCR2 | A/G | 67.6 | −2.02 | 0.33 | 9.3E−10 | 67.8 | −0.72 | 0.43 | 9.0E−02 | 2.3E−07 |
| VWF levels (White participants) | ||||||||||||
| rs61558368 | 2:62414160 | B3GNT2 | T/C | 34.9 | 1.24 | 0.33 | 1.9E−04 | 35.6 | 2.09 | 0.35 | 2.0E−09 | 1.2E−08 |
| Multiphenotype analysis of FVIII levels and VWF levels (cross-population) | ||||||||||||
| rs12979891 | 19:48723999 | RASIP1/FUT1/FUT2 | T/C | 44.2 | 1.37 | 0.30 | 3.9E−06 | 49.0 | 1.83 | 0.32 | 1.8E−08 | 2.6E−09 |
| rs145633869 | 15:43719006 | CKMT1A/PDIA3 | CAGAG/C | 98.3 | 6.55 | 1.22 | 8.0E−08 | 98.1 | 6.15 | 1.26 | 1.1E−06 | 4.1E−09 |
| rs184336448 | 2:198846960 | PLCL1/SATB2 | A/T | 0.43 | 11.01 | 2.53 | 1.3E−05 | 0.53 | 14.61 | 2.59 | 1.6E−08 | 4.4E−09 |
Gene shows the closest genes at each locus; alleles show the coded/noncoded alleles; frequency (Freq.) and beta apply to the coded alleles. SE refers to the standard error of the beta.