Causes of death
| Cause of death . | Total . | BR . | Ibrutinib . | IR . |
|---|---|---|---|---|
| Death following progressive disease∗ | 29 | 15 | 7 | 7 |
| Disease progression | 8 | 5 | 1 | 2 |
| Secondary cancer | 21 | 10 | 6 | 5 |
| Infection | 13 | 3 | 4 | 6 |
| Myocardial infarction | 1 | 0 | 1 | 0 |
| Hemorrhage | 4 | 0 | 1 | 3 |
| Other† | 10 | 2 | 3 | 5 |
| Unexplained/unwitnessed | 16 | 3 | 8 | 5 |
| Cause of death . | Total . | BR . | Ibrutinib . | IR . |
|---|---|---|---|---|
| Death following progressive disease∗ | 29 | 15 | 7 | 7 |
| Disease progression | 8 | 5 | 1 | 2 |
| Secondary cancer | 21 | 10 | 6 | 5 |
| Infection | 13 | 3 | 4 | 6 |
| Myocardial infarction | 1 | 0 | 1 | 0 |
| Hemorrhage | 4 | 0 | 1 | 3 |
| Other† | 10 | 2 | 3 | 5 |
| Unexplained/unwitnessed | 16 | 3 | 8 | 5 |
Sites were not required to report details surrounding deaths for patients after progression; these categories were merged unless death was reported as secondary cancer.
Other causes of death on the BR arm include chronic kidney disease (1) and site unable to provide further information (1). Other causes of death on the ibrutinib arm include multiple comorbidities (1), multiorgan failure (1), and site inability to provide further information (1). Other causes of death on the IR arm include dementia (1), obstructive uropathy (1), suicide (1), complications of endoscopy (1), and complications of splenectomy (1).