Prevalence of MS-MGUS by sociodemographic, comorbidity, and lifestyle factors
| . | . | MS-MGUS . | All MS-positive cases . |
|---|---|---|---|
| Characteristic | n | n (row %) | n (row %) |
| Total cohort | 2628 | 237 (9%) | 948 (36%) |
| Age, y | |||
| <50 | 609 | 23 (4%) | 141 (23%) |
| ≥50 | 2019 | 214 (11%) | 807 (40%) |
| Sex | |||
| Female | 1918 | 154 (8%) | 681 (36%) |
| Male | 710 | 83 (12%) | 267 (38%) |
| Race∗ | |||
| Black | 158 | 23 (15%) | 63 (40%) |
| White | 2441 | 210 (9%) | 874 (36%) |
| Other | 88 | 9 (10%) | 30 (34%) |
| Ethnicity† | |||
| Hispanic | 58 | 4 (7%) | 15 (26%) |
| Non-Hispanic | 2567 | 233 (9%) | 933 (36%) |
| College graduate | |||
| No | 746 | 66 (9%) | 303 (41%) |
| Yes | 1882 | 171 (9%) | 645 (34%) |
| Annual family income | |||
| <$50 000 | 277 | 31 (11%) | 119 (43%) |
| ≥$50 000 | 2057 | 185 (9%) | 727 (35%) |
| Unsure/declined‡ | 294 | 21 (7%) | 102 (35%) |
| Region† | |||
| Midwest | 542 | 42 (8%) | 186 (34%) |
| Northeast | 931 | 75 (8%) | 329 (35%) |
| South | 721 | 75 (10%) | 276 (38%) |
| West | 433 | 45 (10%) | 157 (36%) |
| BMI group, kg/m2 | |||
| Underweight, <18.5 | 26 | 0 (0%) | 10 (38%) |
| Normal weight, 18.5 to <25 | 973 | 71 (7%) | 316 (32%) |
| Overweight, 25 to <30 | 924 | 82 (9%) | 348 (38%) |
| Obesity, ≥30 | 705 | 84 (12%) | 274 (39%) |
| Hypertension† | |||
| Yes | 812 | 98 (12%) | 352 (43%) |
| No | 1803 | 139 (8%) | 592 (33%) |
| High cholesterol† | |||
| Yes | 1027 | 116 (11%) | 394 (38%) |
| No | 1590 | 121 (8%) | 551 (35%) |
| High triglycerides† | |||
| Yes | 465 | 56 (12%) | 173 (37%) |
| No | 2130 | 176 (8%) | 761 (36%) |
| Diabetes mellitus† | |||
| Yes | 114 | 17 (15%) | 47 (41%) |
| No | 2492 | 216 (9%) | 892 (36%) |
| Smoking status† | |||
| Never | 1866 | 162 (9%) | 623 (33%) |
| Past | 695 | 68 (10%) | 293 (42%) |
| Current | 62 | 7 (11%) | 31 (50%) |
| Smoking pack-years† | |||
| Never | 1866 | 162 (9%) | 623 (33%) |
| ≤30 | 619 | 54 (9%) | 251 (41%) |
| >30 | 135 | 21 (16%) | 73 (54%) |
| Average alcohol intake, g per day† | |||
| Nondrinker | 703 | 66 (9%) | 261 (37%) |
| 0.1 to <5.0 | 789 | 63 (8%) | 269 (34%) |
| 5.0 to <15.0 | 654 | 54 (9%) | 241 (37%) |
| ≥15.0 | 474 | 54 (11%) | 174 (37%) |
| Physical activity, MET-hours per week† | |||
| <10.5 | 794 | 81 (10%) | 305 (38%) |
| 10.5 to <31.5 | 814 | 83 (10%) | 296 (36%) |
| 31.5 to <52.5 | 466 | 36 (8%) | 173 (37%) |
| 52.5 to 73.5 | 249 | 23 (9%) | 82 (33%) |
| ≥73.5 | 302 | 14 (5%) | 91 (30%) |
| Sleep, hours per day† | |||
| <6 | 162 | 25 (15%) | 71 (44%) |
| ≥6 | 2458 | 212 (9%) | 876 (36%) |
| Snore† | |||
| Few nights per week or less | 2040 | 176 (9%) | 719 (35%) |
| Most/almost every night(s) | 565 | 59 (10%) | 220 (39%) |
| . | . | MS-MGUS . | All MS-positive cases . |
|---|---|---|---|
| Characteristic | n | n (row %) | n (row %) |
| Total cohort | 2628 | 237 (9%) | 948 (36%) |
| Age, y | |||
| <50 | 609 | 23 (4%) | 141 (23%) |
| ≥50 | 2019 | 214 (11%) | 807 (40%) |
| Sex | |||
| Female | 1918 | 154 (8%) | 681 (36%) |
| Male | 710 | 83 (12%) | 267 (38%) |
| Race∗ | |||
| Black | 158 | 23 (15%) | 63 (40%) |
| White | 2441 | 210 (9%) | 874 (36%) |
| Other | 88 | 9 (10%) | 30 (34%) |
| Ethnicity† | |||
| Hispanic | 58 | 4 (7%) | 15 (26%) |
| Non-Hispanic | 2567 | 233 (9%) | 933 (36%) |
| College graduate | |||
| No | 746 | 66 (9%) | 303 (41%) |
| Yes | 1882 | 171 (9%) | 645 (34%) |
| Annual family income | |||
| <$50 000 | 277 | 31 (11%) | 119 (43%) |
| ≥$50 000 | 2057 | 185 (9%) | 727 (35%) |
| Unsure/declined‡ | 294 | 21 (7%) | 102 (35%) |
| Region† | |||
| Midwest | 542 | 42 (8%) | 186 (34%) |
| Northeast | 931 | 75 (8%) | 329 (35%) |
| South | 721 | 75 (10%) | 276 (38%) |
| West | 433 | 45 (10%) | 157 (36%) |
| BMI group, kg/m2 | |||
| Underweight, <18.5 | 26 | 0 (0%) | 10 (38%) |
| Normal weight, 18.5 to <25 | 973 | 71 (7%) | 316 (32%) |
| Overweight, 25 to <30 | 924 | 82 (9%) | 348 (38%) |
| Obesity, ≥30 | 705 | 84 (12%) | 274 (39%) |
| Hypertension† | |||
| Yes | 812 | 98 (12%) | 352 (43%) |
| No | 1803 | 139 (8%) | 592 (33%) |
| High cholesterol† | |||
| Yes | 1027 | 116 (11%) | 394 (38%) |
| No | 1590 | 121 (8%) | 551 (35%) |
| High triglycerides† | |||
| Yes | 465 | 56 (12%) | 173 (37%) |
| No | 2130 | 176 (8%) | 761 (36%) |
| Diabetes mellitus† | |||
| Yes | 114 | 17 (15%) | 47 (41%) |
| No | 2492 | 216 (9%) | 892 (36%) |
| Smoking status† | |||
| Never | 1866 | 162 (9%) | 623 (33%) |
| Past | 695 | 68 (10%) | 293 (42%) |
| Current | 62 | 7 (11%) | 31 (50%) |
| Smoking pack-years† | |||
| Never | 1866 | 162 (9%) | 623 (33%) |
| ≤30 | 619 | 54 (9%) | 251 (41%) |
| >30 | 135 | 21 (16%) | 73 (54%) |
| Average alcohol intake, g per day† | |||
| Nondrinker | 703 | 66 (9%) | 261 (37%) |
| 0.1 to <5.0 | 789 | 63 (8%) | 269 (34%) |
| 5.0 to <15.0 | 654 | 54 (9%) | 241 (37%) |
| ≥15.0 | 474 | 54 (11%) | 174 (37%) |
| Physical activity, MET-hours per week† | |||
| <10.5 | 794 | 81 (10%) | 305 (38%) |
| 10.5 to <31.5 | 814 | 83 (10%) | 296 (36%) |
| 31.5 to <52.5 | 466 | 36 (8%) | 173 (37%) |
| 52.5 to 73.5 | 249 | 23 (9%) | 82 (33%) |
| ≥73.5 | 302 | 14 (5%) | 91 (30%) |
| Sleep, hours per day† | |||
| <6 | 162 | 25 (15%) | 71 (44%) |
| ≥6 | 2458 | 212 (9%) | 876 (36%) |
| Snore† | |||
| Few nights per week or less | 2040 | 176 (9%) | 719 (35%) |
| Most/almost every night(s) | 565 | 59 (10%) | 220 (39%) |
MS-MGUS defined as M-protein concentration of >0.2 g/L); MS-positive, defines as MS-detected monoclonal gammopathies across all M-protein concentration levels.
Participants were able to indicate >1 race.
Numbers do not sum to the total cohort size because of missing values (i.e., no response was provided).
Participants chose “Don’t know/Not sure” or “Decline to respond” as responses on the survey.