Stratified models for PFS and OS of individual IPI risk factors
| Risk factor . | PFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||
| Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | |
| Age, y | ||||||||
| ≤60 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| >60 | 1.615 (1.393-1.872) | 1.400 (1.206-1.626) | 2.008 (1.682-2.398) | 1.760 (1.472-2.104) | ||||
| Ann Arbor stage | ||||||||
| Ⅰ-Ⅱ | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| Ⅲ-Ⅳ | 3.157 (2.689-3.707) | 2.083 (1.730-2.507) | 3.703 (3.032-4.522) | 2.228 (1.775-2.797) | ||||
| Extranodal involvement | ||||||||
| 0-1 | Reference | < .0001 | Reference | .029 | Reference | < .0001 | Reference | .073 |
| ≥ 2 | 2.288 (1.965-2.664) | 1.209 (1.020-1.433) | 2.433 (2.036-2.908) | 1.197 (0.984-1.456) | ||||
| Serum LDH | ||||||||
| Normal | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| >1 × ULN | 2.928 (2.506-3.421) | 1.960 (1.656-2.320) | 3.765 (3.100-4.574) | 2.416 (1.960-2.979) | ||||
| ECOG performance status | ||||||||
| 0-1 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| ≥2 | 2.721 (2.260-3.277) | 1.712 (1.414-2.074) | 3.159 (2.563-3.894) | 1.888 (1.523-2.341) | ||||
| Risk factor . | PFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||
| Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | |
| Age, y | ||||||||
| ≤60 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| >60 | 1.615 (1.393-1.872) | 1.400 (1.206-1.626) | 2.008 (1.682-2.398) | 1.760 (1.472-2.104) | ||||
| Ann Arbor stage | ||||||||
| Ⅰ-Ⅱ | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| Ⅲ-Ⅳ | 3.157 (2.689-3.707) | 2.083 (1.730-2.507) | 3.703 (3.032-4.522) | 2.228 (1.775-2.797) | ||||
| Extranodal involvement | ||||||||
| 0-1 | Reference | < .0001 | Reference | .029 | Reference | < .0001 | Reference | .073 |
| ≥ 2 | 2.288 (1.965-2.664) | 1.209 (1.020-1.433) | 2.433 (2.036-2.908) | 1.197 (0.984-1.456) | ||||
| Serum LDH | ||||||||
| Normal | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| >1 × ULN | 2.928 (2.506-3.421) | 1.960 (1.656-2.320) | 3.765 (3.100-4.574) | 2.416 (1.960-2.979) | ||||
| ECOG performance status | ||||||||
| 0-1 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 | Reference | < .0001 |
| ≥2 | 2.721 (2.260-3.277) | 1.712 (1.414-2.074) | 3.159 (2.563-3.894) | 1.888 (1.523-2.341) | ||||
N = 1932
CI, confidence interval; ULN, upper limit of normal.