Histopathological features and genetics of 75 patients with LBCL-IRF4+
| Variable . | Number of patients . | % . |
|---|---|---|
| Growth pattern | ||
| Purely follicular | 14 | 18.7 |
| Diffuse | 47 | 62.7 |
| Follicular and diffuse | 12 | 16.0 |
| Not available | 2 | 2.7 |
| CD10 expression | ||
| Positive | 43 | 57.3 |
| Negative | 31 | 41.3 |
| Not available | 1 | 1.3 |
| CD20 expression | ||
| Positive | 73 | 97.3 |
| Negative | 1 | 1.3 |
| Not available | 1 | 1.3 |
| BCL6 expression | ||
| Positive | 60 | 80.0 |
| Negative | 2 | 2.7 |
| Not available | 13 | 17.3 |
| BCL2 expression | ||
| Positive | 52 | 69.3 |
| Negative | 19 | 25.3 |
| Not available | 4 | 5.3 |
| CD5 expression | ||
| Positive | 14 | 18.7 |
| Negative | 22 | 29.3 |
| Not available | 39 | 52.0 |
| IRF4rearrangement | ||
| Positive∗ | 73 | 97.3 |
| Negative | 2 | 2.7 |
| IRF4fusion gene partner | ||
| IGH | 12 | 16.4 |
| IGK | 0 | - |
| IGL | 0 | - |
| Not available | 61 | 83.6 |
| MYCrearrangement | ||
| Positive | 0 | - |
| Negative | 57 | 76.0 |
| Not available | 18 | 24.0 |
| BCL6rearrangement | ||
| Positive | 3 | 4.0 |
| Negative | 35 | 46.7 |
| Not available | 37 | 49.3 |
| BCL2rearrangement | ||
| Positive | 0 | - |
| Negative | 42 | 56.0 |
| Not available | 33 | 44.0 |
| Variable . | Number of patients . | % . |
|---|---|---|
| Growth pattern | ||
| Purely follicular | 14 | 18.7 |
| Diffuse | 47 | 62.7 |
| Follicular and diffuse | 12 | 16.0 |
| Not available | 2 | 2.7 |
| CD10 expression | ||
| Positive | 43 | 57.3 |
| Negative | 31 | 41.3 |
| Not available | 1 | 1.3 |
| CD20 expression | ||
| Positive | 73 | 97.3 |
| Negative | 1 | 1.3 |
| Not available | 1 | 1.3 |
| BCL6 expression | ||
| Positive | 60 | 80.0 |
| Negative | 2 | 2.7 |
| Not available | 13 | 17.3 |
| BCL2 expression | ||
| Positive | 52 | 69.3 |
| Negative | 19 | 25.3 |
| Not available | 4 | 5.3 |
| CD5 expression | ||
| Positive | 14 | 18.7 |
| Negative | 22 | 29.3 |
| Not available | 39 | 52.0 |
| IRF4rearrangement | ||
| Positive∗ | 73 | 97.3 |
| Negative | 2 | 2.7 |
| IRF4fusion gene partner | ||
| IGH | 12 | 16.4 |
| IGK | 0 | - |
| IGL | 0 | - |
| Not available | 61 | 83.6 |
| MYCrearrangement | ||
| Positive | 0 | - |
| Negative | 57 | 76.0 |
| Not available | 18 | 24.0 |
| BCL6rearrangement | ||
| Positive | 3 | 4.0 |
| Negative | 35 | 46.7 |
| Not available | 37 | 49.3 |
| BCL2rearrangement | ||
| Positive | 0 | - |
| Negative | 42 | 56.0 |
| Not available | 33 | 44.0 |
Proven in 72/73 cases by fluorescence in-situ hybridization analysis and in 1 case by next-generation sequencing.