Summary of acute hematologic and nonhematologic toxicities
| Acute toxicity . | Grade 1-2 . | Grade 3-4 . |
|---|---|---|
| R-CHOP + IT lyposomal cytarabine | ||
| Neutropenia | 1 | 16 |
| Anemia | 8 | - |
| Thrombocytopenia | 2 | |
| Febrile neutropenia | - | 6 |
| Fatigue | 10 | 1 |
| Nausea/anorexia | 12 | 1 |
| Peripheral neuropathy | 12 | 3 |
| Neurotoxicity | 1 | - |
| Headache | 15 | 1 |
| Vomiting | 2 | - |
| Arachnoiditis | 1 | 1 |
| Syncope | - | 1 |
| Fever of unknown origin | 7 | 1 |
| Infection∗ | 5 | 3 |
| Liver enzymes | 5 | 2 |
| Diarrhea | 6 | - |
| Constipation | 10 | 1 |
| Atrial fibrillation | 1 | 2 |
| IV high-dose MTX | ||
| Leukopenia | 2 | - |
| Neutropenia | 1 | 3 |
| Anemia | 2 | - |
| Peripheral neuropathy | 4 | 1 |
| Nephrotoxicity | 2 | 1 |
| Fever of unknown origin | 4 | - |
| Infection∗ | 3 | - |
| Mucositis | 3 | 1 |
| Diarrhea | 2 | - |
| Intracranial hemorrhage | - | 1 |
| Acute toxicity . | Grade 1-2 . | Grade 3-4 . |
|---|---|---|
| R-CHOP + IT lyposomal cytarabine | ||
| Neutropenia | 1 | 16 |
| Anemia | 8 | - |
| Thrombocytopenia | 2 | |
| Febrile neutropenia | - | 6 |
| Fatigue | 10 | 1 |
| Nausea/anorexia | 12 | 1 |
| Peripheral neuropathy | 12 | 3 |
| Neurotoxicity | 1 | - |
| Headache | 15 | 1 |
| Vomiting | 2 | - |
| Arachnoiditis | 1 | 1 |
| Syncope | - | 1 |
| Fever of unknown origin | 7 | 1 |
| Infection∗ | 5 | 3 |
| Liver enzymes | 5 | 2 |
| Diarrhea | 6 | - |
| Constipation | 10 | 1 |
| Atrial fibrillation | 1 | 2 |
| IV high-dose MTX | ||
| Leukopenia | 2 | - |
| Neutropenia | 1 | 3 |
| Anemia | 2 | - |
| Peripheral neuropathy | 4 | 1 |
| Nephrotoxicity | 2 | 1 |
| Fever of unknown origin | 4 | - |
| Infection∗ | 3 | - |
| Mucositis | 3 | 1 |
| Diarrhea | 2 | - |
| Intracranial hemorrhage | - | 1 |
Pneumonia G2 (1 case), G3 (3 cases); Herpes Zoster virus infection G2 (1 case); soft tissue G2 (1 case); and urinary tract infection G2 (2 cases).