Simulation study results for C50901 and C50904 (Control Arm) assessing different imaging schedules
| Follow-up schedule . | C50901 . | ||
|---|---|---|---|
| Average median PFS (% difference from true median PFS) . | Absolute difference from true median PFS (mo) . | Bias (MSE) . | |
| S1: every 6 mo for 2 y then annually | 2.07 (8.3%) | 1.9 | 0.16 (0.13) |
| S2: every 8 mo for 2 y then annually | 2.11 (10.7%) | 2.4 | 0.20 (0.14) |
| S3: annually | 2.22 (16.2%) | 3.7 | 0.31 (0.18) |
| Follow-up schedule . | C50901 . | ||
|---|---|---|---|
| Average median PFS (% difference from true median PFS) . | Absolute difference from true median PFS (mo) . | Bias (MSE) . | |
| S1: every 6 mo for 2 y then annually | 2.07 (8.3%) | 1.9 | 0.16 (0.13) |
| S2: every 8 mo for 2 y then annually | 2.11 (10.7%) | 2.4 | 0.20 (0.14) |
| S3: annually | 2.22 (16.2%) | 3.7 | 0.31 (0.18) |
| Follow-up schedule . | C50904, Control Arm . | ||
|---|---|---|---|
| Average median PFS (% difference from true median PFS) . | Absolute difference from true median PFS (mo) . | Bias (MSE) . | |
| S1: every 6 mo for 2 y then annually | 4.20 (2.5%) | 1.2 | 0.10 (0.63) |
| S2: every 8 mo for 2 y then annually | 4.16 (1.5%) | 0.7 | 0.06 (0.60) |
| S3: annually | 4.09 (−0.3%) | 0.1 | −0.01 (0.56) |
| Follow-up schedule . | C50904, Control Arm . | ||
|---|---|---|---|
| Average median PFS (% difference from true median PFS) . | Absolute difference from true median PFS (mo) . | Bias (MSE) . | |
| S1: every 6 mo for 2 y then annually | 4.20 (2.5%) | 1.2 | 0.10 (0.63) |
| S2: every 8 mo for 2 y then annually | 4.16 (1.5%) | 0.7 | 0.06 (0.60) |
| S3: annually | 4.09 (−0.3%) | 0.1 | −0.01 (0.56) |
True median PFS for the C50901 arm was 1.91 years.
True median PFS for the C50904 (Control Arm) was 4.10 years.
m, months; MSE, mean squared error; PFS, progression-free survival; y, years.