Table 1. Definitions of HR TA-TMA and... | American Society of Hematology

Table 1.

Definitions of HR TA-TMA and multiorgan dysfunction

HR TA-TMA
Proteinuria and elevated sC5-b9, or
Proteinura or elevated sC5b-9 and any evidence of 2 organs or more in dysfunction.
Cardiac	Pericardial effusion requiring medical or surgical intervention Pulmonary hypertension on ECHO
Pulmonary	Diffuse alveolar hemorrhage Requiring noninvasive ventilation or intubation for >12 h
Renal	Doubling of serum creatinine HTN requiring a continuous drip for >12 h Renal replacement
Neurologic	Altered mental status PRES Seizures
Gastroenterology	Hemorrhage secondary to TA-TMA requiring medical therapy

HR TA-TMA
Proteinuria and elevated sC5-b9, or
Proteinura or elevated sC5b-9 and any evidence of 2 organs or more in dysfunction.
Cardiac	Pericardial effusion requiring medical or surgical intervention Pulmonary hypertension on ECHO
Pulmonary	Diffuse alveolar hemorrhage Requiring noninvasive ventilation or intubation for >12 h
Renal	Doubling of serum creatinine HTN requiring a continuous drip for >12 h Renal replacement
Neurologic	Altered mental status PRES Seizures
Gastroenterology	Hemorrhage secondary to TA-TMA requiring medical therapy

This definition was modified from prior publications.

ECHO, echocardiogram; HTN, hypertension; PRES, posterior reversible encephalopathy syndrome.