Multivariable analyses
| MVA model . | Feature . | PFS . | OS . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio . | Lower CI . | Upper CI . | P . | Events (n) . | Hazard ratio . | Lower CI . | Upper CI . | P . | Events (n) . | ||
| Model 1 (n = 76) | Age, y | 1.00 | 0.96 | 1.05 | .93 | 33 | 1.01 | 0.96 | 1.07 | .62 | 26 |
| Concordance index PFS: 0.73; OS 0.76 | ECOG score 2-4 vs 0-1 | 3.18 | 1.41 | 7.18 | <.01 | 33 | 2.67 | 1.13 | 6.30 | .03 | 26 |
| LDH: upper limit of normal ratio (>1 vs <1) | 1.06 | 0.46 | 2.46 | .88 | 33 | 1.84 | 0.75 | 4.49 | .18 | 26 | |
| WCC ≥ 10 | 1.51 | 0.68 | 3.32 | .31 | 33 | 0.62 | 0.24 | 1.59 | .32 | 26 | |
| Blastoid/ pleomorphic histology | 3.72 | 1.48 | 9.31 | <.01 | 33 | 3.05 | 1.14 | 8.18 | .03 | 26 | |
| Ki67 > 30% vs < 30% | 0.89 | 0.39 | 2.01 | .78 | 33 | 1.20 | 0.52 | 2.78 | .67 | 26 | |
| Model 2 (n= 117) | Age, y | 1.02 | 0.98 | 1.06 | .35 | 49 | 1.05 | 1.01 | 1.10 | .03 | 39 |
| Concordance index PFS: 0.69; OS: 0.73 | ECOG score 2-4 vs 0-1 | 2.43 | 1.30 | 4.52 | <.01 | 49 | 1.98 | 1.00 | 3.93 | .05 | 39 |
| LDH: upper limit of normal ratio (>1 vs <1) | 1.32 | 0.69 | 2.51 | .40 | 49 | 1.82 | 0.87 | 3.82 | .11 | 39 | |
| Presence of ≥1 high-risk feature(s) | 2.10 | 1.15 | 3.82 | .02 | 49 | 2.26 | 1.14 | 4.48 | .02 | 39 | |
| Model 3 (n = 117) | Age, y | 1.02 | 0.98 | 1.05 | .44 | 49 | 1.05 | 1.00 | 1.09 | .05 | 39 |
| Concordance index PFS: 0.72; OS: 0.74 | ECOG 2-4 vs 0-1 | 2.31 | 1.21 | 4.40 | .01 | 49 | 1.93 | 0.96 | 3.89 | .07 | 39 |
| LDH: upper limit of normal ratio (>1 vs <1) | 1.32 | 0.69 | 2.55 | .40 | 49 | 1.94 | 0.92 | 4.09 | .08 | 39 | |
| Blastoid/pleomorphic histology | 3.30 | 1.70 | 6.40 | <.01 | 49 | 2.35 | 1.12 | 4.94 | .02 | 39 | |
| MVA model . | Feature . | PFS . | OS . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio . | Lower CI . | Upper CI . | P . | Events (n) . | Hazard ratio . | Lower CI . | Upper CI . | P . | Events (n) . | ||
| Model 1 (n = 76) | Age, y | 1.00 | 0.96 | 1.05 | .93 | 33 | 1.01 | 0.96 | 1.07 | .62 | 26 |
| Concordance index PFS: 0.73; OS 0.76 | ECOG score 2-4 vs 0-1 | 3.18 | 1.41 | 7.18 | <.01 | 33 | 2.67 | 1.13 | 6.30 | .03 | 26 |
| LDH: upper limit of normal ratio (>1 vs <1) | 1.06 | 0.46 | 2.46 | .88 | 33 | 1.84 | 0.75 | 4.49 | .18 | 26 | |
| WCC ≥ 10 | 1.51 | 0.68 | 3.32 | .31 | 33 | 0.62 | 0.24 | 1.59 | .32 | 26 | |
| Blastoid/ pleomorphic histology | 3.72 | 1.48 | 9.31 | <.01 | 33 | 3.05 | 1.14 | 8.18 | .03 | 26 | |
| Ki67 > 30% vs < 30% | 0.89 | 0.39 | 2.01 | .78 | 33 | 1.20 | 0.52 | 2.78 | .67 | 26 | |
| Model 2 (n= 117) | Age, y | 1.02 | 0.98 | 1.06 | .35 | 49 | 1.05 | 1.01 | 1.10 | .03 | 39 |
| Concordance index PFS: 0.69; OS: 0.73 | ECOG score 2-4 vs 0-1 | 2.43 | 1.30 | 4.52 | <.01 | 49 | 1.98 | 1.00 | 3.93 | .05 | 39 |
| LDH: upper limit of normal ratio (>1 vs <1) | 1.32 | 0.69 | 2.51 | .40 | 49 | 1.82 | 0.87 | 3.82 | .11 | 39 | |
| Presence of ≥1 high-risk feature(s) | 2.10 | 1.15 | 3.82 | .02 | 49 | 2.26 | 1.14 | 4.48 | .02 | 39 | |
| Model 3 (n = 117) | Age, y | 1.02 | 0.98 | 1.05 | .44 | 49 | 1.05 | 1.00 | 1.09 | .05 | 39 |
| Concordance index PFS: 0.72; OS: 0.74 | ECOG 2-4 vs 0-1 | 2.31 | 1.21 | 4.40 | .01 | 49 | 1.93 | 0.96 | 3.89 | .07 | 39 |
| LDH: upper limit of normal ratio (>1 vs <1) | 1.32 | 0.69 | 2.55 | .40 | 49 | 1.94 | 0.92 | 4.09 | .08 | 39 | |
| Blastoid/pleomorphic histology | 3.30 | 1.70 | 6.40 | <.01 | 49 | 2.35 | 1.12 | 4.94 | .02 | 39 | |
MVA, multivariable analysis; WCC, white cell count.