Outcomes of the study cohort
| . | All patients n (%) . | sMut n (%) . | No sMut n (%) . | P value . |
|---|---|---|---|---|
| Response | ||||
| CR/CRi | 192 (82.4) | 30 (69.7) | 162 (85.3) | .025 |
| PR/NR | 38 (16.3) | 10 (23.3) | 28 (14.7) | .176 |
| Unknown | 3 (1.3) | 3 (7.0) | 0 | - |
| Best NPM1 MRD by PCR | ||||
| Positive | 38 (16.3) | 4 (9.3) | 34 (17.9) | .251 |
| Negative | 57 (24.5) | 9 (20.9) | 48 (25.3) | .695 |
| Unknown | 138 (59.2) | 30 (69.8) | 108 (56.8) | - |
| Median OS, mo | 35.5 | 15.3 | 43.7 |
| . | All patients n (%) . | sMut n (%) . | No sMut n (%) . | P value . |
|---|---|---|---|---|
| Response | ||||
| CR/CRi | 192 (82.4) | 30 (69.7) | 162 (85.3) | .025 |
| PR/NR | 38 (16.3) | 10 (23.3) | 28 (14.7) | .176 |
| Unknown | 3 (1.3) | 3 (7.0) | 0 | - |
| Best NPM1 MRD by PCR | ||||
| Positive | 38 (16.3) | 4 (9.3) | 34 (17.9) | .251 |
| Negative | 57 (24.5) | 9 (20.9) | 48 (25.3) | .695 |
| Unknown | 138 (59.2) | 30 (69.8) | 108 (56.8) | - |
| Median OS, mo | 35.5 | 15.3 | 43.7 |
sMut: ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, and ZRSR2.
PCR, polymerase chain reaction.