Table 1.

The association between patient characteristics and letermovir use

CharacteristicsPatients with letermovir prophylaxis (n = 236)Patients without CMV prophylaxis (n = 1958)P value
Patient age at HSCT, y, median 54.0 51.0 <.001 
Sex mismatch   .74 
Female to male 48 (20.3%) 419 (21.4%)  
Other 188 (79.7%) 1539 (78.6%)  
Underlying disease   .24 
Acute myeloid leukemia 104 (44.1%) 867 (44.3%)  
Acute lymphoblastic leukemia 47 (19.9%) 341 (17.4%)  
Aplastic anemia 9 (3.8%) 50 (2.6%)  
Chronic myeloid leukemia 3 (1.3%) 75 (3.8%)  
Myelodysplastic syndromes 36 (15.3%) 327 (16.7%)  
Other 11 (4.7%) 93 (4.7%)  
Disease risk   .84 
Low 109 (46.2%) 909 (46.4%)  
High 127 (53.8%) 1027 (52.5%)  
NA 22 (1.1%)  
Number of HSCTs   .93 
193 (81.8%) 1590 (81.2%)  
43 (18.2%) 368 (18.8%)  
Graft source   .004 
BM 80 (33.9%) 868 (44.3%)  
PBSCs 75 (31.8%) 582 (29.7%)  
CB 81 (34.3%) 508 (25.9%)  
HLA   .009 
Matched 76 (32.2%) 804 (41.1%)  
Mismatched 160 (67.8%) 1154 (58.9%)  
Relationship   .77 
Related 75 (31.8%) 644 (32.9%)  
Unrelated 161 (68.2%) 1314 (67.1%)  
Performance status   .51 
0-1 214 (90.7%) 1741 (88.9%)  
2-4 22 (9.3%) 217 (11.1%)  
HCT-CI   .36 
0-2 178 (75.4%) 1531 (78.2%)  
≥3 58 (24.6%) 427 (21.8%)  
Donor CMV IgG   .006 
Positive 98 (41.5%) 750 (38.3%)  
Negative 63 (26.7%) 767 (39.2%)  
Unknown 75 (31.8%) 441 (22.5%)  
Conditioning intensity   .098 
Myeloablative 109 (46.2%) 1020 (52.1%)  
Reduced intensity 127 (53.8%) 938 (47.9%)  
ATG use before HSCT   <.001 
Yes 66 (28.0%) 323 (16.5%)  
No 170 (72.0%) 1635 (83.5%)  
Acute GVHD, grade   1.0 
0-1 148 (62.7%) 1197 (61.1%)  
2-4 86 (36.4%) 699 (35.7%)  
NA 2 (0.8%) 62 (3.2%)  
CharacteristicsPatients with letermovir prophylaxis (n = 236)Patients without CMV prophylaxis (n = 1958)P value
Patient age at HSCT, y, median 54.0 51.0 <.001 
Sex mismatch   .74 
Female to male 48 (20.3%) 419 (21.4%)  
Other 188 (79.7%) 1539 (78.6%)  
Underlying disease   .24 
Acute myeloid leukemia 104 (44.1%) 867 (44.3%)  
Acute lymphoblastic leukemia 47 (19.9%) 341 (17.4%)  
Aplastic anemia 9 (3.8%) 50 (2.6%)  
Chronic myeloid leukemia 3 (1.3%) 75 (3.8%)  
Myelodysplastic syndromes 36 (15.3%) 327 (16.7%)  
Other 11 (4.7%) 93 (4.7%)  
Disease risk   .84 
Low 109 (46.2%) 909 (46.4%)  
High 127 (53.8%) 1027 (52.5%)  
NA 22 (1.1%)  
Number of HSCTs   .93 
193 (81.8%) 1590 (81.2%)  
43 (18.2%) 368 (18.8%)  
Graft source   .004 
BM 80 (33.9%) 868 (44.3%)  
PBSCs 75 (31.8%) 582 (29.7%)  
CB 81 (34.3%) 508 (25.9%)  
HLA   .009 
Matched 76 (32.2%) 804 (41.1%)  
Mismatched 160 (67.8%) 1154 (58.9%)  
Relationship   .77 
Related 75 (31.8%) 644 (32.9%)  
Unrelated 161 (68.2%) 1314 (67.1%)  
Performance status   .51 
0-1 214 (90.7%) 1741 (88.9%)  
2-4 22 (9.3%) 217 (11.1%)  
HCT-CI   .36 
0-2 178 (75.4%) 1531 (78.2%)  
≥3 58 (24.6%) 427 (21.8%)  
Donor CMV IgG   .006 
Positive 98 (41.5%) 750 (38.3%)  
Negative 63 (26.7%) 767 (39.2%)  
Unknown 75 (31.8%) 441 (22.5%)  
Conditioning intensity   .098 
Myeloablative 109 (46.2%) 1020 (52.1%)  
Reduced intensity 127 (53.8%) 938 (47.9%)  
ATG use before HSCT   <.001 
Yes 66 (28.0%) 323 (16.5%)  
No 170 (72.0%) 1635 (83.5%)  
Acute GVHD, grade   1.0 
0-1 148 (62.7%) 1197 (61.1%)  
2-4 86 (36.4%) 699 (35.7%)  
NA 2 (0.8%) 62 (3.2%)  

HCT-CI, hematopoietic cell transplantation-specific comorbidity index; NA, not assessed.

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