CD4 nadir and ART duration and odds of CHIP presence
| Predictor . | OR . | CI-low . | CI-high . | P value . |
|---|---|---|---|---|
| CD4 nadir (cells per mm3) | ||||
| ≥350 | [ref] | — | — | — |
| 200-349 | 1.63 | 1.06 | 2.55 | .03 |
| 50-199 | 1.39 | 0.911 | 2.17 | .136 |
| <50 | 1.91 | 1.21 | 3.05 | .006 |
| CD4 nadir (cells per mm3) | ||||
| Ordinal linear | 1.49 | 1.09 | 2.06 | .014 |
| Total ART duration (y) | ||||
| ≥10 | [ref] | — | — | — |
| 5-10 | 0.911 | 0.708 | 1.24 | .563 |
| <5 | 0.731 | 0.492 | 1.06 | .109 |
| Baseline ART duration (years - numeric) | 0.981 | 0.942 | 1.02 | .346 |
| Predictor . | OR . | CI-low . | CI-high . | P value . |
|---|---|---|---|---|
| CD4 nadir (cells per mm3) | ||||
| ≥350 | [ref] | — | — | — |
| 200-349 | 1.63 | 1.06 | 2.55 | .03 |
| 50-199 | 1.39 | 0.911 | 2.17 | .136 |
| <50 | 1.91 | 1.21 | 3.05 | .006 |
| CD4 nadir (cells per mm3) | ||||
| Ordinal linear | 1.49 | 1.09 | 2.06 | .014 |
| Total ART duration (y) | ||||
| ≥10 | [ref] | — | — | — |
| 5-10 | 0.911 | 0.708 | 1.24 | .563 |
| <5 | 0.731 | 0.492 | 1.06 | .109 |
| Baseline ART duration (years - numeric) | 0.981 | 0.942 | 1.02 | .346 |
Results of multiple regression models adjusting for age, natal sex, and smoking status associating CD4 nadir with presence of CHIP, structured as a categorical and ordinal variable, and associating both total ART duration and baseline ART duration with presence of CHIP.
CD4, cluster of differentiation 4.