Patient characteristics
| Total, N . | 85 . |
|---|---|
| Age, median (range), y | 55 (38-65) |
| Sex, N (%) | |
| Female | 29 (34.1) |
| Male | 56 (65.9) |
| Race, N (%) | |
| Caucasian | 83 (97.6) |
| Asian | 2 (2.4) |
| Ethnicity, N (%) | |
| Hispanic or Latino | 3 (3.5) |
| Non-Hispanic or Latino | 81 (95.3) |
| Unknown | 1 (1.2) |
| ECOG PS | |
| 0 | 50 (58.8) |
| 1 | 35 (41.2) |
| Rai stage, N (%) | |
| 0-2 | 42 (49.4) |
| 3-4 | 40 (47.1) |
| Missing | 3 (3.5) |
| Bulky disease (any target lesion > 5 cm), N (%) | 27 (31.8) |
| IGHV status, N (%) | |
| Mutated | 34 (40.0) |
| Unmutated | 45 (52.9) |
| Indeterminate | 6 (7.1) |
| Hierarchical FISH at enrollment, N (%) | |
| Deletion 13q | 37 (43.5) |
| Normal | 15 (17.6) |
| Trisomy 12 | 12 (14.1) |
| Deletion 11q | 16 (18.8) |
| Deletion 17p | 4 (4.7) |
| Missing | 1 (1.2) |
| Complex karyotype (3 or more aberrations), N (%) | 14 (16.9) |
| Driver gene mutation at enrollment, N mutated/N tested (%) | |
| TP53 mutation | 3/81 (3.7) |
| NOTCH1 mutation | 5/58 (8.6) |
| MYD88 mutation | 2/19 (10.5) |
| Laboratory values at enrollment, median (range) | |
| White blood cell count (109/L) | 109 (3-776) |
| Hemoglobin (g/dL) | 12 (7.8-15.9) |
| Platelet count (109/L) | 127 (43-366) |
| Beta-2 microglobulin (mg/dL) | 3.4 (0.3-12.6) |
| Total, N . | 85 . |
|---|---|
| Age, median (range), y | 55 (38-65) |
| Sex, N (%) | |
| Female | 29 (34.1) |
| Male | 56 (65.9) |
| Race, N (%) | |
| Caucasian | 83 (97.6) |
| Asian | 2 (2.4) |
| Ethnicity, N (%) | |
| Hispanic or Latino | 3 (3.5) |
| Non-Hispanic or Latino | 81 (95.3) |
| Unknown | 1 (1.2) |
| ECOG PS | |
| 0 | 50 (58.8) |
| 1 | 35 (41.2) |
| Rai stage, N (%) | |
| 0-2 | 42 (49.4) |
| 3-4 | 40 (47.1) |
| Missing | 3 (3.5) |
| Bulky disease (any target lesion > 5 cm), N (%) | 27 (31.8) |
| IGHV status, N (%) | |
| Mutated | 34 (40.0) |
| Unmutated | 45 (52.9) |
| Indeterminate | 6 (7.1) |
| Hierarchical FISH at enrollment, N (%) | |
| Deletion 13q | 37 (43.5) |
| Normal | 15 (17.6) |
| Trisomy 12 | 12 (14.1) |
| Deletion 11q | 16 (18.8) |
| Deletion 17p | 4 (4.7) |
| Missing | 1 (1.2) |
| Complex karyotype (3 or more aberrations), N (%) | 14 (16.9) |
| Driver gene mutation at enrollment, N mutated/N tested (%) | |
| TP53 mutation | 3/81 (3.7) |
| NOTCH1 mutation | 5/58 (8.6) |
| MYD88 mutation | 2/19 (10.5) |
| Laboratory values at enrollment, median (range) | |
| White blood cell count (109/L) | 109 (3-776) |
| Hemoglobin (g/dL) | 12 (7.8-15.9) |
| Platelet count (109/L) | 127 (43-366) |
| Beta-2 microglobulin (mg/dL) | 3.4 (0.3-12.6) |
ECOG PS, ECOG performance status; N, number of patients.