Table 1.

Clinical factors at rebiopsy in all patients and patients with r-PET analysis

All rebiopsies (N = 397)Rebiopsies with r-PET analysis (N = 290)
Diagnosis to rebiopsy >5 y 143 (36%) 107 (37%) 
History of composite/transformed histology 39 (10%) 27 (9%) 
Any treatment 361 (91%) 270 (93%) 
Last treatment to rebiopsy >6 mo 218/361 (60%) 156/270 (58%) 
Response to most recent treatment based on most recent prior imaging   
Complete remission 260/361 (72%) 114/270 (42%) 
Noncomplete remission  101/361 (28%) 156/270 (58%) 
Clinical factors at time of rebiopsy   
Palpable lymphadenopathy  168/385(44%) 118/283 (41%) 
B symptoms  38/388 (10%) 31/287 (11%) 
Elevated LDH  110/276 (40%) 88/212 (42%) 
Extranodal disease  214/372 (58%) 179 (62%) 
New site of disease compared to most recent prior imaging  206/308 (67%) 167/243 (58%) 
>1 site of suspected disease 262 (66%) 217 (77%) 
r-PET DS (4-5) NA 265 (91%) 
Rebiopsy site was most FDG-avid site  NA 151/280 (54%) 
All rebiopsies (N = 397)Rebiopsies with r-PET analysis (N = 290)
Diagnosis to rebiopsy >5 y 143 (36%) 107 (37%) 
History of composite/transformed histology 39 (10%) 27 (9%) 
Any treatment 361 (91%) 270 (93%) 
Last treatment to rebiopsy >6 mo 218/361 (60%) 156/270 (58%) 
Response to most recent treatment based on most recent prior imaging   
Complete remission 260/361 (72%) 114/270 (42%) 
Noncomplete remission  101/361 (28%) 156/270 (58%) 
Clinical factors at time of rebiopsy   
Palpable lymphadenopathy  168/385(44%) 118/283 (41%) 
B symptoms  38/388 (10%) 31/287 (11%) 
Elevated LDH  110/276 (40%) 88/212 (42%) 
Extranodal disease  214/372 (58%) 179 (62%) 
New site of disease compared to most recent prior imaging  206/308 (67%) 167/243 (58%) 
>1 site of suspected disease 262 (66%) 217 (77%) 
r-PET DS (4-5) NA 265 (91%) 
Rebiopsy site was most FDG-avid site  NA 151/280 (54%) 

Noncomplete remission includes partial response, stable disease and progressive disease.

Data were not available in all patients—denominators are listed in the table.

In 10 patients, rebiopsy site was excised before r-PET.

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