Outcomes in descriptive and cohort studies in pregnant people with β TM and β TI
| . | β TM . | β TI . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Group . | Outcomes . | Study, n . | Pregnancies, n . | Proportion % (95% CI) . | I2 (P value) . | Study, n . | Study pregnancy, n . | Proportion % (95% CI) . | I2 (P value) . |
| Maternal | Maternal mortality | 6 | 94 | 3.0 (0.6-7.2) | 0 (.63) | - | - | - | - |
| Pre-eclampsia | 6 | 193 | 11.3 (6.2-15.3) | 36.8% (.16) | - | - | - | - | |
| Gestational diabetes | 9 | 259 | 3.9 (1.3- 8.0) | 46.4% (.06) | - | - | - | - | |
| VTE | 7 | 219 | 0.92 (0.1-2.6) | 0 (.70) | 6 | 254 | 3.7 (1.2-7.5) | 33.2% (.19) | |
| Heart failure | 6 | 227 | 1.6 (0.4-3.7) | 2.4% (0.40) | 3 | 160 | 1.1 (0.1-3.3) | 0 (.72) | |
| Cesarean delivery | 9 | 221 | 83.9 (65.2-96.2) | 90.3% (< .0001) | 5 | 216 | 67.0 (66.0-77.2) | 59.0% (.045) | |
| Fetal | Spontaneous miscarriage | 7 | 172 | 6.1% (3.4-11.4) | 36.8% (.16) | 5 | 317 | 9.5 (3.8-17.5) | 64.5% (.02) |
| Live birth | 12 | 342 | 99.2 (98.0-99.9) | 0 (.99) | 5 | 213 | 99.5 (98.1-100.0) | 0 (.93) | |
| Still birth | 12 | 342 | 1.3 (0.4-2.7) | 0 (.97) | 1.2 (0.20-3.1) | 0 (.48) | |||
| Small for gestational age (<10 percentile) | 8 | 226 | 18.1 (8.8- 29.9) | 75.9% (.0001) | 5 | 213 | 14.5 (2.3-34.8) | 90.5% (< .0001) | |
| Preterm birth (<37 wk) | 8 | 215 | 25.2 (12.3-41.0) | 83.0% (< .0001) | 5 | 213 | 8.9 (0.5-26.2) | 90.1% (< .0001) | |
| Preterm birth (<37 wk)- excluding multiples | 8 | 196 | 21.1 (11.8-32.3) | 66.3% (.004) | - | - | - | - | |
| NICU admission | 3 | 114 | 32.1 (2.4-75.2) | 94.8% (< .0001) | 1 | 49 | 14.3 | - | |
| . | β TM . | β TI . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Group . | Outcomes . | Study, n . | Pregnancies, n . | Proportion % (95% CI) . | I2 (P value) . | Study, n . | Study pregnancy, n . | Proportion % (95% CI) . | I2 (P value) . |
| Maternal | Maternal mortality | 6 | 94 | 3.0 (0.6-7.2) | 0 (.63) | - | - | - | - |
| Pre-eclampsia | 6 | 193 | 11.3 (6.2-15.3) | 36.8% (.16) | - | - | - | - | |
| Gestational diabetes | 9 | 259 | 3.9 (1.3- 8.0) | 46.4% (.06) | - | - | - | - | |
| VTE | 7 | 219 | 0.92 (0.1-2.6) | 0 (.70) | 6 | 254 | 3.7 (1.2-7.5) | 33.2% (.19) | |
| Heart failure | 6 | 227 | 1.6 (0.4-3.7) | 2.4% (0.40) | 3 | 160 | 1.1 (0.1-3.3) | 0 (.72) | |
| Cesarean delivery | 9 | 221 | 83.9 (65.2-96.2) | 90.3% (< .0001) | 5 | 216 | 67.0 (66.0-77.2) | 59.0% (.045) | |
| Fetal | Spontaneous miscarriage | 7 | 172 | 6.1% (3.4-11.4) | 36.8% (.16) | 5 | 317 | 9.5 (3.8-17.5) | 64.5% (.02) |
| Live birth | 12 | 342 | 99.2 (98.0-99.9) | 0 (.99) | 5 | 213 | 99.5 (98.1-100.0) | 0 (.93) | |
| Still birth | 12 | 342 | 1.3 (0.4-2.7) | 0 (.97) | 1.2 (0.20-3.1) | 0 (.48) | |||
| Small for gestational age (<10 percentile) | 8 | 226 | 18.1 (8.8- 29.9) | 75.9% (.0001) | 5 | 213 | 14.5 (2.3-34.8) | 90.5% (< .0001) | |
| Preterm birth (<37 wk) | 8 | 215 | 25.2 (12.3-41.0) | 83.0% (< .0001) | 5 | 213 | 8.9 (0.5-26.2) | 90.1% (< .0001) | |
| Preterm birth (<37 wk)- excluding multiples | 8 | 196 | 21.1 (11.8-32.3) | 66.3% (.004) | - | - | - | - | |
| NICU admission | 3 | 114 | 32.1 (2.4-75.2) | 94.8% (< .0001) | 1 | 49 | 14.3 | - | |
NICU, neonatal intensive care unit.