Table 2. Treatment-related AEs in... | American Society of Hematology

Table 2.

Treatment-related AEs in greater than or equal to 10% of the patients or any grade 3 to 4–related AEs, regardless of causality

AEs, N (%)	Overall Ph− (N = 10)	Overall Ph+ (N = 16)	G1 Ph⁻	G1 Ph⁺	G2 Ph⁻	G2 Ph⁺	G3 Ph⁻	G3 Ph⁺	G4 Ph⁻	G4 Ph⁺
ALT/AST level elevation	6 (60)	12 (75)	6 (60)	4 (25)	0	6 (38)	0	2 (13)	0	0
Thrombocytopenia	7 (70)	10 (63)	1 (10)	5 (31)	2 (20)	0	2 (20)	3 (19)	2 (20)	2 (13)
Neutropenia	5 (50)	4 (25)	0	1 (6)	1 (10)	0	0	0	4 (40)	3 (19)
Fatigue	2 (20)	2 (13)	2 (20)	0	0	2 (13)	0	0	0	0
Abdominal pain/distension	0	3 (19)	0	2 (13)	0	0	0	1 (6)	0	0
Constipation	1 (10)	2 (13)	1 (10)	1 (6)	0	1 (6)	0	0	0	0
Hepatic SOS∗	0	2 (13)	0	0	0	0	0	1 (6)	0	0
Hypertension	1 (10)	1 (6)	0	0	0	1 (6)	1 (10)	0	0	0
Anemia	1 (10)	0	0	0	0	0	1 (10)	0	0	0

AEs, N (%)	Overall Ph− (N = 10)	Overall Ph+ (N = 16)	G1 Ph⁻	G1 Ph⁺	G2 Ph⁻	G2 Ph⁺	G3 Ph⁻	G3 Ph⁺	G4 Ph⁻	G4 Ph⁺
ALT/AST level elevation	6 (60)	12 (75)	6 (60)	4 (25)	0	6 (38)	0	2 (13)	0	0
Thrombocytopenia	7 (70)	10 (63)	1 (10)	5 (31)	2 (20)	0	2 (20)	3 (19)	2 (20)	2 (13)
Neutropenia	5 (50)	4 (25)	0	1 (6)	1 (10)	0	0	0	4 (40)	3 (19)
Fatigue	2 (20)	2 (13)	2 (20)	0	0	2 (13)	0	0	0	0
Abdominal pain/distension	0	3 (19)	0	2 (13)	0	0	0	1 (6)	0	0
Constipation	1 (10)	2 (13)	1 (10)	1 (6)	0	1 (6)	0	0	0	0
Hepatic SOS∗	0	2 (13)	0	0	0	0	0	1 (6)	0	0
Hypertension	1 (10)	1 (6)	0	0	0	1 (6)	1 (10)	0	0	0
Anemia	1 (10)	0	0	0	0	0	1 (10)	0	0	0

ALT/AST, alanine aminotransferase/aspartate aminotransferase; G, grade; Ph⁻, Philadelphia chromosome–negative; Ph⁺, Philadelphia chromosome–positive.

One patient had grade 5 hepatic SOS.