Logistic regression model evaluating relation of laboratory parameters with VOE
| . | OR . | aOR . | ||||
|---|---|---|---|---|---|---|
| VOE . | OR . | 95% CI . | P . | OR . | 95% CI . | P . |
| Pediatric cohort | ||||||
| PoS (10 mmHg ↑) | 1.35 | 0.99-1.85 | .064 | 1.35 | 0.99-1.85 | .071 |
| EImin (0.1 EI ↑) | 0.60 | 0.42-0.85 | .003∗ | 0.60 | 0.42-0.85 | .004∗ |
| EImax (0.1 EI ↑) | 0.84 | 0.60-1.17 | .307 | 0.84 | 0.60-1.17 | .309 |
| Blood viscosity (1.0 cP ↑)† | 1.36 | 0.93-1.98 | .111 | 1.29 | 0.88-1.87 | .189 |
| HVR | 0.79 | 0.51-1.23 | .297 | 0.83 | 0.51-1.35 | .452 |
| Hb (1.0 g/dL ↑) | 1.06 | 0.85-1.32 | .627 | 1.05 | 0.84-1.32 | .642 |
| HbF (10.0% ↑)‡ | 0.51 | 0.29-0.90 | .019 | 0.50 | 0.28-0.89 | .018 |
| MCV (10 fl ↑) | 1.02 | 0.79-1.32 | .899 | 0.98 | 0.74-1.29 | .898 |
| MCHC (1.0 g/dL ↑) | 0.99 | 0.79-1.25 | .952 | 1.04 | 0.83-1.30 | .754 |
| MCH (10.0 pg ↑) | 0.64 | 0.31-1.33 | .238 | 0.56 | 0.26-1.20 | .135 |
| ARC (100 × 109/L ↑) | 1.42 | 1.14-1.76 | .002∗ | 1.48 | 1.18-1.86 | .001∗ |
| DRBCs (1.0% ↑) | 1.07 | 0.98-1.18 | .151 | 1.08 | 0.98-1.18 | .126 |
| Adult cohort | ||||||
| PoS (10 mmHg ↑) | 2.33 | 1.11-4.92 | .026 | 2.22 | 1.00-4.97 | .050 |
| EImin (0.1 EI ↑) | 0.48 | 0.22-1.03 | .062 | 0.52 | 0.21-1.29 | .160 |
| EImax (0.1 EI ↑) | 0.25 | 0.09-0.69 | .007∗ | 0.32 | 0.11-0.89 | .011 |
| Blood viscosity (1.0 cP ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
| HVR | n/a | n/a | n/a | n/a | n/a | n/a |
| Hb (1.0 g/dL ↑) | 0.92 | 0.57-1.49 | .735 | 0.96 | 0.56-1.64 | .881 |
| HbF (10.0% ↑) | 0.35 | 0.17-0.71 | .004∗ | 0.32 | 0.14 - 0.72 | .010 |
| MCV (10 fl ↑) | 0.79 | 0.56-1.13 | .200 | 1.02 | 0.64-1.63 | .920 |
| MCHC (1.0 g/dL ↑) | 1.16 | 0.75-1.78 | .512 | 1.30 | 0.80-2.11 | .283 |
| MCH (10.0 pg ↑) | 0.96 | 0.88-1.05 | .353 | 1.01 | 0.93-1.12 | .909 |
| ARC (100 × 109/L ↑) | 1.01 | 0.95-1.08 | .669 | 0.99 | 0.92-1.07 | .748 |
| DRBCs (1.0% ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
| . | OR . | aOR . | ||||
|---|---|---|---|---|---|---|
| VOE . | OR . | 95% CI . | P . | OR . | 95% CI . | P . |
| Pediatric cohort | ||||||
| PoS (10 mmHg ↑) | 1.35 | 0.99-1.85 | .064 | 1.35 | 0.99-1.85 | .071 |
| EImin (0.1 EI ↑) | 0.60 | 0.42-0.85 | .003∗ | 0.60 | 0.42-0.85 | .004∗ |
| EImax (0.1 EI ↑) | 0.84 | 0.60-1.17 | .307 | 0.84 | 0.60-1.17 | .309 |
| Blood viscosity (1.0 cP ↑)† | 1.36 | 0.93-1.98 | .111 | 1.29 | 0.88-1.87 | .189 |
| HVR | 0.79 | 0.51-1.23 | .297 | 0.83 | 0.51-1.35 | .452 |
| Hb (1.0 g/dL ↑) | 1.06 | 0.85-1.32 | .627 | 1.05 | 0.84-1.32 | .642 |
| HbF (10.0% ↑)‡ | 0.51 | 0.29-0.90 | .019 | 0.50 | 0.28-0.89 | .018 |
| MCV (10 fl ↑) | 1.02 | 0.79-1.32 | .899 | 0.98 | 0.74-1.29 | .898 |
| MCHC (1.0 g/dL ↑) | 0.99 | 0.79-1.25 | .952 | 1.04 | 0.83-1.30 | .754 |
| MCH (10.0 pg ↑) | 0.64 | 0.31-1.33 | .238 | 0.56 | 0.26-1.20 | .135 |
| ARC (100 × 109/L ↑) | 1.42 | 1.14-1.76 | .002∗ | 1.48 | 1.18-1.86 | .001∗ |
| DRBCs (1.0% ↑) | 1.07 | 0.98-1.18 | .151 | 1.08 | 0.98-1.18 | .126 |
| Adult cohort | ||||||
| PoS (10 mmHg ↑) | 2.33 | 1.11-4.92 | .026 | 2.22 | 1.00-4.97 | .050 |
| EImin (0.1 EI ↑) | 0.48 | 0.22-1.03 | .062 | 0.52 | 0.21-1.29 | .160 |
| EImax (0.1 EI ↑) | 0.25 | 0.09-0.69 | .007∗ | 0.32 | 0.11-0.89 | .011 |
| Blood viscosity (1.0 cP ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
| HVR | n/a | n/a | n/a | n/a | n/a | n/a |
| Hb (1.0 g/dL ↑) | 0.92 | 0.57-1.49 | .735 | 0.96 | 0.56-1.64 | .881 |
| HbF (10.0% ↑) | 0.35 | 0.17-0.71 | .004∗ | 0.32 | 0.14 - 0.72 | .010 |
| MCV (10 fl ↑) | 0.79 | 0.56-1.13 | .200 | 1.02 | 0.64-1.63 | .920 |
| MCHC (1.0 g/dL ↑) | 1.16 | 0.75-1.78 | .512 | 1.30 | 0.80-2.11 | .283 |
| MCH (10.0 pg ↑) | 0.96 | 0.88-1.05 | .353 | 1.01 | 0.93-1.12 | .909 |
| ARC (100 × 109/L ↑) | 1.01 | 0.95-1.08 | .669 | 0.99 | 0.92-1.07 | .748 |
| DRBCs (1.0% ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
A logistic regression analysis was performed to calculate ORs for oxygen gradient ektacytometry–derived parameters, blood viscosity, DRBCs, HbF, and hemocytometry parameters in relation to occurrence of VOEs in the last 2 years. aORs were corrected for hydroxyurea therapy.
cP, centipoize; HVR, hematocrit to viscosity ratio; MCHC, mean corpuscular Hb concentration; MCH, mean corpuscular Hb; n/a, not addressed.
OR is significant after correcting for multiple testing (false discovery rate analysis).
Data of 110 individuals available.
Data of 90 individuals available.