Logistic regression model evaluating relation of laboratory parameters with more than 1 type of acute complication
| . | OR . | aOR . | ||||
|---|---|---|---|---|---|---|
| >1 type of acute complication∗ . | OR . | 95% CI . | P . | OR . | 95% CI . | P . |
| Pediatric cohort | ||||||
| PoS (10 mmHg ↑) | 1.75 | 1.23-2.49 | .002† | 1.65 | 1.16-2.35 | .006† |
| EImin (0.1 EI ↑) | 0.45 | 0.30-0.68 | <.0001† | 0.50 | 0.33-0.76 | .001† |
| EImax (0.1 EI ↑) | 0.64 | 0.45-0.92 | .014† | 0.70 | 0.49-1.00 | .052 |
| Blood viscosity (1.0 cP ↑)‡ | 1.18 | 0.81-1.71 | .400 | 1.06 | 0.71-1.58 | .770 |
| HVR | 0.77 | 0.48-1.24 | .285 | 0.88 | 0.54-1.43 | .598 |
| Hb (1.0 g/dL ↑) | 1.04 | 0.83-1.30 | .752 | 1.02 | 0.81-1.29 | .859 |
| HbF (10.0% ↑)§ | 0.55 | 0.31-0.97 | .039 | 0.76 | 0.40-1.44 | .396 |
| MCV (10 fl ↑) | 1.16 | 0.90-1.50 | .240 | 1.04 | 0.81-1.34 | .744 |
| MCHC (1.0 g/dL ↑) | 1.03 | 0.80-1.31 | .836 | 1.06 | 0.82-1.38 | .643 |
| MCH (10.0 pg ↑) | 0.94 | 0.45-1.98 | .868 | 0.71 | 0.32-1.56 | .395 |
| ARC (100 ×109/L ↑) | 1.35 | 1.09-1.67 | .005† | 1.34 | 1.07-1.67 | .011† |
| Dense RBCs (1.0% ↑) | 1.15 | 1.04-1.26 | .006† | 1.10 | 0.99-1.22 | .071 |
| Adult cohort | ||||||
| PoS (10 mmHg ↑) | 2.46 | 1.26-4.79 | .009 | 3.00 | 1.32-6.83 | .015 |
| EImin (0.1 EI ↑) | 0.41 | 0.16-1.02 | .053 | 0.39 | 0.13-1.14 | .085 |
| EImax (0.1 EI ↑) | 0.38 | 0.17-0.98 | .016 | 0.33 | 0.12-0.92 | .035 |
| Blood viscosity (1.0 cP ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
| HVR | n/a | n/a | n/a | n/a | n/a | n/a |
| Hb (1.0 g/dL ↑) | 0.91 | 0.55-1.48 | .692 | 0.91 | 0.55-1.49 | .706 |
| HbF (10.0% ↑) | 0.51 | 0.24-1.08 | .077 | 0.49 | 0.19-1.28 | .149 |
| MCV (10 fl ↑) | 1.02 | 0.71-1.48 | .918 | 1.27 | 0.78-2.08 | .334 |
| MCHC (1.0 g/dL ↑) | 1.16 | 0.73-1.83 | .539 | 1.19 | 0.74-1.89 | .478 |
| MCH (10.0 pg ↑) | 1.03 | 0.94-1.13 | .517 | 1.08 | 0.96-1.22 | .183 |
| ARC (100 ×10∗9/L ↑) | 1.04 | 0.97-1.11 | .252 | 1.03 | 0.95-1.11 | .440 |
| Dense RBCs (1.0% ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
| . | OR . | aOR . | ||||
|---|---|---|---|---|---|---|
| >1 type of acute complication∗ . | OR . | 95% CI . | P . | OR . | 95% CI . | P . |
| Pediatric cohort | ||||||
| PoS (10 mmHg ↑) | 1.75 | 1.23-2.49 | .002† | 1.65 | 1.16-2.35 | .006† |
| EImin (0.1 EI ↑) | 0.45 | 0.30-0.68 | <.0001† | 0.50 | 0.33-0.76 | .001† |
| EImax (0.1 EI ↑) | 0.64 | 0.45-0.92 | .014† | 0.70 | 0.49-1.00 | .052 |
| Blood viscosity (1.0 cP ↑)‡ | 1.18 | 0.81-1.71 | .400 | 1.06 | 0.71-1.58 | .770 |
| HVR | 0.77 | 0.48-1.24 | .285 | 0.88 | 0.54-1.43 | .598 |
| Hb (1.0 g/dL ↑) | 1.04 | 0.83-1.30 | .752 | 1.02 | 0.81-1.29 | .859 |
| HbF (10.0% ↑)§ | 0.55 | 0.31-0.97 | .039 | 0.76 | 0.40-1.44 | .396 |
| MCV (10 fl ↑) | 1.16 | 0.90-1.50 | .240 | 1.04 | 0.81-1.34 | .744 |
| MCHC (1.0 g/dL ↑) | 1.03 | 0.80-1.31 | .836 | 1.06 | 0.82-1.38 | .643 |
| MCH (10.0 pg ↑) | 0.94 | 0.45-1.98 | .868 | 0.71 | 0.32-1.56 | .395 |
| ARC (100 ×109/L ↑) | 1.35 | 1.09-1.67 | .005† | 1.34 | 1.07-1.67 | .011† |
| Dense RBCs (1.0% ↑) | 1.15 | 1.04-1.26 | .006† | 1.10 | 0.99-1.22 | .071 |
| Adult cohort | ||||||
| PoS (10 mmHg ↑) | 2.46 | 1.26-4.79 | .009 | 3.00 | 1.32-6.83 | .015 |
| EImin (0.1 EI ↑) | 0.41 | 0.16-1.02 | .053 | 0.39 | 0.13-1.14 | .085 |
| EImax (0.1 EI ↑) | 0.38 | 0.17-0.98 | .016 | 0.33 | 0.12-0.92 | .035 |
| Blood viscosity (1.0 cP ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
| HVR | n/a | n/a | n/a | n/a | n/a | n/a |
| Hb (1.0 g/dL ↑) | 0.91 | 0.55-1.48 | .692 | 0.91 | 0.55-1.49 | .706 |
| HbF (10.0% ↑) | 0.51 | 0.24-1.08 | .077 | 0.49 | 0.19-1.28 | .149 |
| MCV (10 fl ↑) | 1.02 | 0.71-1.48 | .918 | 1.27 | 0.78-2.08 | .334 |
| MCHC (1.0 g/dL ↑) | 1.16 | 0.73-1.83 | .539 | 1.19 | 0.74-1.89 | .478 |
| MCH (10.0 pg ↑) | 1.03 | 0.94-1.13 | .517 | 1.08 | 0.96-1.22 | .183 |
| ARC (100 ×10∗9/L ↑) | 1.04 | 0.97-1.11 | .252 | 1.03 | 0.95-1.11 | .440 |
| Dense RBCs (1.0% ↑) | n/a | n/a | n/a | n/a | n/a | n/a |
A logistic regression analysis was performed to calculate ORs for oxygen gradient ektacytometry–derived parameters, blood viscosity, DRBCs, HbF, and hemocytometry parameters in relation to occurrence of >1 type of acute complication.
aORs were corrected for age and hydroxyurea therapy.
CI, confidence interval; cP, centipoize; HVR, hematocrit to viscosity ratio; MCHC, mean corpuscular Hb concentration; MCH, mean corpuscular Hb.
ACS, VOEs, and/or cerebral infarction.
OR is significant after correcting for multiple testing (False discovery rate analysis).
Data of 110 individuals available.
Data of 90 individuals available.