Characteristics of 19 leukemia cases in offspring with available certification for the diagnosis
| Maternal exposure to anticancer drugs . | Infant or noninfant . | Type and description of leukemia . | Chromosomal abnormalities and/or other genetic alterations . |
|---|---|---|---|
| Yes | Noninfant | BCP-ALL | Complex karyotype |
| BCP-ALL | TCF3-PBX1 | ||
| T-ALL | SIL-TAL1 | ||
| No | Infant | BCP-ALL | Translocation |
| BCP-ALL | KMT2A-AF9 | ||
| DS-ML | Trisomy 21 | ||
| DS-ML | Trisomy 21 | ||
| AML-NOS (AML-M5) | KMT2A-MLLT10 | ||
| MPAL | NA | ||
| Noninfant | BCP-ALL | Normal karyotype | |
| BCP-ALL | TCF3-PBX1 | ||
| BCP-ALL | Hyperdiploid, TCF3-PBX1 | ||
| BCP-ALL | Normal karyotype | ||
| BCP-ALL | Hyperdiploid | ||
| DS-ML | Trisomy 21 | ||
| DS-ML | Trisomy 21, complex karyotype | ||
| DS-ML | Trisomy 21 | ||
| AML-NOS (AML-M7) | NA | ||
| AML-NOS | t(16;21)(p11.2;q22) |
| Maternal exposure to anticancer drugs . | Infant or noninfant . | Type and description of leukemia . | Chromosomal abnormalities and/or other genetic alterations . |
|---|---|---|---|
| Yes | Noninfant | BCP-ALL | Complex karyotype |
| BCP-ALL | TCF3-PBX1 | ||
| T-ALL | SIL-TAL1 | ||
| No | Infant | BCP-ALL | Translocation |
| BCP-ALL | KMT2A-AF9 | ||
| DS-ML | Trisomy 21 | ||
| DS-ML | Trisomy 21 | ||
| AML-NOS (AML-M5) | KMT2A-MLLT10 | ||
| MPAL | NA | ||
| Noninfant | BCP-ALL | Normal karyotype | |
| BCP-ALL | TCF3-PBX1 | ||
| BCP-ALL | Hyperdiploid, TCF3-PBX1 | ||
| BCP-ALL | Normal karyotype | ||
| BCP-ALL | Hyperdiploid | ||
| DS-ML | Trisomy 21 | ||
| DS-ML | Trisomy 21, complex karyotype | ||
| DS-ML | Trisomy 21 | ||
| AML-NOS (AML-M7) | NA | ||
| AML-NOS | t(16;21)(p11.2;q22) |
Information for 1 offspring in the exposed group and 9 offspring in the unexposed group was missing.
Sex and age at the diagnosis are removed from the table to protect personal information.
AML, acute myeloid leukemia, BCP, B-cell precursor; DS-ML, Down syndrome–associated myeloid leukemia; MPAL, mixed phenotype acute leukemia; NA, not applicable; NOS, not otherwise specified; T-ALL, T-cell acute lymphoblastic leukemia.