Clinical questions adapted
| Diagnosis of VTE |
| Diagnosis of PE |
| Diagnosis of PE in individuals with low pretest probability (≤5%) of a first PE |
| Diagnosis of PE in individuals with low pretest probability (≤5%) of recurrent PE |
| Diagnosis of PE in individuals with intermediate pretest probability (∼20%) of a first PE |
| Diagnosis of PE in individuals with high pretest probability (≥50%) of a first PE |
| Diagnosis of PE in individuals with high pretest probability (≥50%) of recurrent PE |
| Diagnosis of DVT |
| Diagnosis of DVT in individuals with low pretest probability (≤10%) of a first DVT |
| Diagnosis of DVT in individuals with low pretest probability (≤10%) of recurrent DVT |
| Diagnosis of DVT in individuals with intermediate pretest probability (∼25%) |
| Diagnosis of DVT in individuals with high pretest probability (≥50%) of a first DVT |
| Diagnosis of DVT in individuals with high pretest probability (≥50%) of recurrent DVT |
| Management of VTE during pregnancy |
| Treatment of acute VTE and superficial venous thrombosis |
| Anticoagulation with LMWH vs no anticoagulation in superficial venous thrombosis |
| Use once-daily vs twice-daily LMWH in VTE |
| Thrombolytic therapy vs anticoagulation alone in PE and hemodynamic failure |
| Thrombolytic therapy vs anticoagulation alone in PE and right ventricular dysfunction |
| Home treatment vs hospital treatment DVT or PE and low risk of complication |
| Management of anticoagulants around the time of delivery |
| Scheduled delivery vs spontaneous labor for women receiving therapeutic-dose LMWH |
| Scheduled delivery vs spontaneous labor for women receiving prophylactic-dose LMWH |
| Anticoagulant use for breastfeeding women |
| One specific drug to be used vs others |
| Prevention of VTE |
| Antepartum prophylaxis vs no prophylaxis for women with previous VTE |
| Postpartum prophylaxis vs no prophylaxis for women with previous VTE |
| Antepartum prophylaxis vs no prophylaxis for women with thrombophilia |
| Postpartum prophylaxis vs no prophylaxis for women with thrombophilia |
| Management of VTE in children |
| Anticoagulation vs no anticoagulation in asymptomatic VTE |
| Thrombolytic therapy vs anticoagulation alone in PE and hemodynamic failure |
| Removal vs no removal of functioning central access in symptomatic associated VTE |
| LMWH vs VKAs as maintenance therapy for VTE |
| Anticoagulation vs no anticoagulation in cerebral sinus venous thrombosis |
| Diagnosis of VTE |
| Diagnosis of PE |
| Diagnosis of PE in individuals with low pretest probability (≤5%) of a first PE |
| Diagnosis of PE in individuals with low pretest probability (≤5%) of recurrent PE |
| Diagnosis of PE in individuals with intermediate pretest probability (∼20%) of a first PE |
| Diagnosis of PE in individuals with high pretest probability (≥50%) of a first PE |
| Diagnosis of PE in individuals with high pretest probability (≥50%) of recurrent PE |
| Diagnosis of DVT |
| Diagnosis of DVT in individuals with low pretest probability (≤10%) of a first DVT |
| Diagnosis of DVT in individuals with low pretest probability (≤10%) of recurrent DVT |
| Diagnosis of DVT in individuals with intermediate pretest probability (∼25%) |
| Diagnosis of DVT in individuals with high pretest probability (≥50%) of a first DVT |
| Diagnosis of DVT in individuals with high pretest probability (≥50%) of recurrent DVT |
| Management of VTE during pregnancy |
| Treatment of acute VTE and superficial venous thrombosis |
| Anticoagulation with LMWH vs no anticoagulation in superficial venous thrombosis |
| Use once-daily vs twice-daily LMWH in VTE |
| Thrombolytic therapy vs anticoagulation alone in PE and hemodynamic failure |
| Thrombolytic therapy vs anticoagulation alone in PE and right ventricular dysfunction |
| Home treatment vs hospital treatment DVT or PE and low risk of complication |
| Management of anticoagulants around the time of delivery |
| Scheduled delivery vs spontaneous labor for women receiving therapeutic-dose LMWH |
| Scheduled delivery vs spontaneous labor for women receiving prophylactic-dose LMWH |
| Anticoagulant use for breastfeeding women |
| One specific drug to be used vs others |
| Prevention of VTE |
| Antepartum prophylaxis vs no prophylaxis for women with previous VTE |
| Postpartum prophylaxis vs no prophylaxis for women with previous VTE |
| Antepartum prophylaxis vs no prophylaxis for women with thrombophilia |
| Postpartum prophylaxis vs no prophylaxis for women with thrombophilia |
| Management of VTE in children |
| Anticoagulation vs no anticoagulation in asymptomatic VTE |
| Thrombolytic therapy vs anticoagulation alone in PE and hemodynamic failure |
| Removal vs no removal of functioning central access in symptomatic associated VTE |
| LMWH vs VKAs as maintenance therapy for VTE |
| Anticoagulation vs no anticoagulation in cerebral sinus venous thrombosis |