Causes of thrombocytopenia in older adults
| Decreased platelet production . | Increased platelet destruction . | Platelet consumption . | Splenic sequestration . |
|---|---|---|---|
| MDS | Primary ITP | Disseminated intravascular coagulation | Splenomegaly |
| Hematologic malignancy | DITP | TMA including TTP, HUS, atypical HUS, systemic sclerosis, and malignant hypertension | |
| Bone marrow metastasis | Secondary ITP associated with rheumatologic disease and infections | Sepsis/infection | |
| Aplastic anemia | Antiphospholipid antibody syndrome | ||
| Drug effect including alcohol | |||
| Nutritional deficiencies (vitamin B12, folate, and copper) | |||
| Liver disease | |||
| Sepsis/infection |
| Decreased platelet production . | Increased platelet destruction . | Platelet consumption . | Splenic sequestration . |
|---|---|---|---|
| MDS | Primary ITP | Disseminated intravascular coagulation | Splenomegaly |
| Hematologic malignancy | DITP | TMA including TTP, HUS, atypical HUS, systemic sclerosis, and malignant hypertension | |
| Bone marrow metastasis | Secondary ITP associated with rheumatologic disease and infections | Sepsis/infection | |
| Aplastic anemia | Antiphospholipid antibody syndrome | ||
| Drug effect including alcohol | |||
| Nutritional deficiencies (vitamin B12, folate, and copper) | |||
| Liver disease | |||
| Sepsis/infection |
HUS, hemolytic uremic syndrome; TTP, thrombocytopenic purpura.