Details on immune reconstitution of the patients given TCRαβ/CD19-depleted haploHSCT
| Variable . | 1 mo . | 3 mo . | 6 mo . | 12 mo . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HaploHSCT . | MFD . | UD . | P value . | HaploHSCT . | MFD . | UD . | P value . | HaploHSCT . | MFD . | UD . | P value . | HaploHSCT . | MFD . | UD . | P value . | |
| CD3+ T cells/μl | 150 (1-1680) | 401 (55-1148) | 239 (24-1776) | <.01 | 234 (19-1727) | 495 (95-2254) | 323 (18-4766) | <.01 | 544 (110-2640) | 719 (210-3561) | 678 (131-8439) | .01 | 1040 (206-5045) | 1477 (305-3469) | 1279 (81-5072) | N.S. |
| CD4+ T cells/μl | 18 (0-542) | 150 (13-471) | 70 (1-863) | <.01 | 57 (2-615) | 165 (19-904) | 87 (0-1139) | <.01 | 169 (51-1186) | 258 (110-1027) | 204 (22-1796) | <.01 | 494 (110-2009) | 565 (117-1537) | 438 (77-1676) | N.S. |
| CD8+ T cells/μl | 29 (0-1024) | 229 (35-766) | 119 (2-1470) | <.01 | 62 (3-1110) | 281 (38-1328) | 191 (2-4118) | <.01 | 208 (25-1602) | 384 (58-2372) | 327 (78-6454) | <.01 | 392 (94-3975) | 625 (82-2286) | 615 (48-4065) | <.01 |
| αβ T cells/μl | 45 (0-812) | 343 (52-963) | 217 (1-1616) | <.01 | 174 (11-1340) | 476 (86-2062) | 290 (5-4274) | <.01 | 452 (78-2146) | 682 (190-3048) | 584 (122-8312) | <.01 | 959 (215-4621) | 1359 (270-3265) | 1052 (110-4853) | N.S. |
| γδ T cells/μl | 93 (0-1335) | 36 (3-176) | 14 (1-352) | <.01 | 50 (1-1313) | 37 (3-253) | 19 (1-320) | <.01 | 78 (4-1865) | 68 (7-482) | 36 (1-487) | <.01 | 97 (4-1305) | 103 (12-1136) | 92 (6-1044) | N.S. |
| CD3-CD56+ NK cells/μl | 176 (10-1813) | 220 (24-1010) | 143 (19-718) | N.S. | 147 (5-1448) | 137 (12-576) | 127 (4-880) | N.S. | 199 (31-2120) | 203 (72-1125) | 155 (8-1535) | N.S. | 237 (43-3116) | 278 (67-1369) | 223 (15-2314) | N.S. |
| CD19+ B cells/μl | 0 (0-110) | 5 (0-328) | 4 (0-251) | <.01 | 1 (0-475) | 110 (1-582) | 47 (0-461) | <.01 | 133 (0-1652) | 301 (0-2794) | 189 (0-2664) | <.01 | 288 (0-1723) | 506 (0-2629) | 355 (0-2199) | .02 |
| Variable . | 1 mo . | 3 mo . | 6 mo . | 12 mo . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HaploHSCT . | MFD . | UD . | P value . | HaploHSCT . | MFD . | UD . | P value . | HaploHSCT . | MFD . | UD . | P value . | HaploHSCT . | MFD . | UD . | P value . | |
| CD3+ T cells/μl | 150 (1-1680) | 401 (55-1148) | 239 (24-1776) | <.01 | 234 (19-1727) | 495 (95-2254) | 323 (18-4766) | <.01 | 544 (110-2640) | 719 (210-3561) | 678 (131-8439) | .01 | 1040 (206-5045) | 1477 (305-3469) | 1279 (81-5072) | N.S. |
| CD4+ T cells/μl | 18 (0-542) | 150 (13-471) | 70 (1-863) | <.01 | 57 (2-615) | 165 (19-904) | 87 (0-1139) | <.01 | 169 (51-1186) | 258 (110-1027) | 204 (22-1796) | <.01 | 494 (110-2009) | 565 (117-1537) | 438 (77-1676) | N.S. |
| CD8+ T cells/μl | 29 (0-1024) | 229 (35-766) | 119 (2-1470) | <.01 | 62 (3-1110) | 281 (38-1328) | 191 (2-4118) | <.01 | 208 (25-1602) | 384 (58-2372) | 327 (78-6454) | <.01 | 392 (94-3975) | 625 (82-2286) | 615 (48-4065) | <.01 |
| αβ T cells/μl | 45 (0-812) | 343 (52-963) | 217 (1-1616) | <.01 | 174 (11-1340) | 476 (86-2062) | 290 (5-4274) | <.01 | 452 (78-2146) | 682 (190-3048) | 584 (122-8312) | <.01 | 959 (215-4621) | 1359 (270-3265) | 1052 (110-4853) | N.S. |
| γδ T cells/μl | 93 (0-1335) | 36 (3-176) | 14 (1-352) | <.01 | 50 (1-1313) | 37 (3-253) | 19 (1-320) | <.01 | 78 (4-1865) | 68 (7-482) | 36 (1-487) | <.01 | 97 (4-1305) | 103 (12-1136) | 92 (6-1044) | N.S. |
| CD3-CD56+ NK cells/μl | 176 (10-1813) | 220 (24-1010) | 143 (19-718) | N.S. | 147 (5-1448) | 137 (12-576) | 127 (4-880) | N.S. | 199 (31-2120) | 203 (72-1125) | 155 (8-1535) | N.S. | 237 (43-3116) | 278 (67-1369) | 223 (15-2314) | N.S. |
| CD19+ B cells/μl | 0 (0-110) | 5 (0-328) | 4 (0-251) | <.01 | 1 (0-475) | 110 (1-582) | 47 (0-461) | <.01 | 133 (0-1652) | 301 (0-2794) | 189 (0-2664) | <.01 | 288 (0-1723) | 506 (0-2629) | 355 (0-2199) | .02 |
Data are given as median (range). Data from other type of transplant performed in the same time period are also reported for comparison.
MFD, matched family donor; N.S., not significant; UD, matched unrelated donor.