Demographic, clinical, and biological characteristics of the first episode of pregnancy-onset TTP in 108 patients
| Demographic features . | iTTP (n = 52) . | uTTP (n = 27) . | cTTP (n = 29) . | Total (N = 108) . | P value . |
|---|---|---|---|---|---|
| Age, y | 29 (8) | 28 (11) | 27 (7) | 28 (8) | ns |
| Gestational age (WG) | 30 (11) | 34 (11) | 30 (8) | 30 (10) | ns |
| Gravidity | 2 (2) | 2 (2) | 1 (1) | 2 (2) | ns |
| Parity | 1 (2) | 1 (1) | 1 (1) | 1 (2) | ns |
| Twin pregnancies | 2/52 (3.8%) | 4/27 (14.8%) | 1/29 (3.5%) | 7/108 (6.5%) | ns |
| Maternal survival | 48/52 (92.3%) | 26/27 (96.2%) | 29/29 (100%) | 103/108 (95%) | ns |
| Fetal survival | 35/50∗ (70%) | 21/27 (77.8%) | 21/29 (72.4%) | 80/106 (75.5%) | ns |
| Clinical features | |||||
| Fever | 17/52 (32.7%) | 9/27 (33.3%) | 2/29 (6.8%) | 28/108 (25.9%) | ns |
| Neurologic symptoms | 30/52 (57.7%) | 13/27 (48.2%) | 7/29 (24%) | 50/108 (46.3%) | ns |
| High blood pressure | 7/52 (13.5%) | 14/27 (51.8%) | 8/29 (27.6%) | 29/108 (26.8%) | <.05 |
| Abdominal pain | 19/52 (36.5%) | 12/27 (44.4%) | 11/29 (37.9%) | 42/108 (38.9%) | ns |
| AKI | 17/52 (32.7%) | 18/27 (66.7%) | 9/29 (31%) | 44/108 (40.7%) | <.05 |
| Biological features | |||||
| Platelet count (×109/L) | 13 (9) | 34 (34) | 19 (12) | 18 (20) | <.0001 |
| Hemoglobin level (g/dL) | 7.2 (2.1) | 8.1 (1.8) | 7.9 (2.2) | 7.7 (2.1) | ns |
| Serum creatinine (μmol/L) | 80 (87) | 202 (300) | 79 (48) | 94 (24-500, 119) | <.005 |
| LDH (U/L) | 1588 (1460) | 1400 (2400) | 1000 (2325) | 1400 (1992) | ns |
| Demographic features . | iTTP (n = 52) . | uTTP (n = 27) . | cTTP (n = 29) . | Total (N = 108) . | P value . |
|---|---|---|---|---|---|
| Age, y | 29 (8) | 28 (11) | 27 (7) | 28 (8) | ns |
| Gestational age (WG) | 30 (11) | 34 (11) | 30 (8) | 30 (10) | ns |
| Gravidity | 2 (2) | 2 (2) | 1 (1) | 2 (2) | ns |
| Parity | 1 (2) | 1 (1) | 1 (1) | 1 (2) | ns |
| Twin pregnancies | 2/52 (3.8%) | 4/27 (14.8%) | 1/29 (3.5%) | 7/108 (6.5%) | ns |
| Maternal survival | 48/52 (92.3%) | 26/27 (96.2%) | 29/29 (100%) | 103/108 (95%) | ns |
| Fetal survival | 35/50∗ (70%) | 21/27 (77.8%) | 21/29 (72.4%) | 80/106 (75.5%) | ns |
| Clinical features | |||||
| Fever | 17/52 (32.7%) | 9/27 (33.3%) | 2/29 (6.8%) | 28/108 (25.9%) | ns |
| Neurologic symptoms | 30/52 (57.7%) | 13/27 (48.2%) | 7/29 (24%) | 50/108 (46.3%) | ns |
| High blood pressure | 7/52 (13.5%) | 14/27 (51.8%) | 8/29 (27.6%) | 29/108 (26.8%) | <.05 |
| Abdominal pain | 19/52 (36.5%) | 12/27 (44.4%) | 11/29 (37.9%) | 42/108 (38.9%) | ns |
| AKI | 17/52 (32.7%) | 18/27 (66.7%) | 9/29 (31%) | 44/108 (40.7%) | <.05 |
| Biological features | |||||
| Platelet count (×109/L) | 13 (9) | 34 (34) | 19 (12) | 18 (20) | <.0001 |
| Hemoglobin level (g/dL) | 7.2 (2.1) | 8.1 (1.8) | 7.9 (2.2) | 7.7 (2.1) | ns |
| Serum creatinine (μmol/L) | 80 (87) | 202 (300) | 79 (48) | 94 (24-500, 119) | <.005 |
| LDH (U/L) | 1588 (1460) | 1400 (2400) | 1000 (2325) | 1400 (1992) | ns |
Categorical variables are presented as n/number of patients and percentage. Continuous variables are presented as median (IQR).
AKI, acute kidney injury; LDH, lactate dehydrogenase; ns, nonsignificant.
Two pregnancies were ended (abortion). P from Mann-Whitney U test or Kruskal-Wallis test for count data.