Multivariable Cox regression HRs for all-cause mortality
. | Pooled . | MSK . | ISMMS . | ||||
---|---|---|---|---|---|---|---|
Events/patients . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
Entire cohort | |||||||
Diabetes | |||||||
Nondiabetic | 1299/4593 | Reference | Reference | Reference | |||
Diabetic | 253/790 | 1.27 (1.11-1.47) | <.001 | 1.26 (1.06-1.48) | .008 | 1.31 (1.00-1.71) | .048 |
Race | |||||||
Black | 295/1001 | Reference | Reference | Reference | |||
White | 1257/4382 | 0.88 (0.77-1.01) | .059 | 0.92 (0.77-1.09) | .331 | 0.83 (0.68-1.02) | .077 |
Gender | |||||||
Female | 630/2381 | Reference | Reference | Reference | |||
Male | 922/3002 | 1.23 (1.10. 1.39) | <.001 | 1.29 (1.14-1.47) | <.001 | 1.14 (0.95-1.36) | .163 |
Age (y) | |||||||
<45 | 55/326 | Reference | Reference | Reference | |||
45-60 | 362/1558 | 1.52 (1.13-2.04) | .006 | 1.59 (1.13-2.25) | <.001 | 1.33 (0.75-2.35) | .007 |
>60 | 1135/3499 | 2.41 (1.82-3.20) | <.001 | 2.51 (1.81-3.50) | .009 | 2.15 (1.23-3.74) | .330 |
BMI | |||||||
Normal | 499/1612 | Reference | Reference | Reference | |||
Overweight | 588/2079 | 0.83 (0.70-0.99) | .035 | 0.77 (0.66-0.90) | .001 | 0.92 (0.75-1.13) | .415 |
Obese | 442/1603 | 0.82 (0.71-0.93) | .003 | 0.81 (0.69-0.96) | .013 | 0.83 (0.66-1.05) | .116 |
Underweight | 23/89 | 1.08 (0.69-1.69) | .725 | 1.09 (0.63-1.89) | .756 | 1.07 (0.50-2.28) | .871 |
Black cohort | |||||||
Diabetes | |||||||
Nondiabetic | 67/247 | Reference | Reference | Reference | |||
Diabetic | 228/754 | 1.08 (0.81-1.44) | .584 | 1.01 (0.70-1.46) | .942 | 1.21 (0.76-1.91) | .428 |
Gender | |||||||
Female | 147/549 | Reference | Reference | Reference | |||
Male | 148/452 | 1.30 (1.03-1.65) | .028 | 1.19 (0.86-1.64) | .286 | 1.44 (1.02-2.03) | .040 |
Age (y) | |||||||
<45 | 16/81 | Reference | Reference | Reference | |||
45-60 | 182/569 | 1.59 (0.92-2.73) | .095 | 1.59 (0.84-3.01) | .030 | 1.58 (0.56-4.42) | .126 |
>60 | 97/351 | 2.03 (1.20-3.42) | .008 | 1.97 (1.07-3.62) | .154 | 2.20 (0.80-6.05) | .387 |
BMI | |||||||
Normal | 96/253 | Reference | Reference | Reference | |||
Overweight | 104/374 | 0.68 (0.52-0.90) | .007 | 0.63 (0.43-0.92) | .016 | 0.75 (0.50-1.14) | .181 |
Obese | 89/361 | 0.62 (0.46-0.83) | .002 | 0.57 (0.38-0.86) | .007 | 0.68 (0.43-1.05) | .083 |
Underweight | 6/13 | 1.88 (0.81-4.33) | .139 | 1.82 (0.65-5.11) | .255 | 1.99 (0.48-8.27) | .347 |
White cohort | |||||||
Diabetes | |||||||
Nondiabetic | 186/543 | Reference | Reference | Reference | |||
Diabetic | 1071/3839 | 1.35 (1.15-1.59) | <.001 | 1.33 (1.11-1.61) | .003 | 1.41 (1.02-1.96) | .040 |
Gender | |||||||
Female | 483/1832 | Reference | Reference | Reference | |||
Male | 774/2550 | 1.16 (0.93-1.46) | .194 | 1.29 (1.12-1.49) | <.001 | 1.02 (0.82-1.26) | .878 |
Age (y) | |||||||
<45 | 39/245 | Reference | Reference | Reference | |||
45-60 | 953/2930 | 1.51 (1.06-2.14) | .023 | 1.63 (1.08-2.46) | <.001 | 1.21 (0.61-2.41) | .032 |
>60 | 265/1207 | 2.51 (1.79-3.53) | <.001 | 2.69 (1.81-4.00) | .022 | 2.07 (1.07-4.03) | .592 |
BMI | |||||||
Normal | 403/1359 | Reference | Reference | Reference | |||
Overweight | 484/1705 | 0.87 (0.70-1.10) | .248 | 0.79 (0.67-0.94) | .006 | 1.00 (0.78-1.27) | .970 |
Obese | 353/1242 | 0.88 (0.76-1.02) | .095 | 0.86 (0.72-1.03) | .095 | 0.93 (0.71-1.21) | .575 |
Underweight | 17/76 | 0.93 (0.55-1.57) | .794 | 0.95 (0.50-1.82) | .880 | 0.90 (0.37-2.21) | .816 |
. | Pooled . | MSK . | ISMMS . | ||||
---|---|---|---|---|---|---|---|
Events/patients . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
Entire cohort | |||||||
Diabetes | |||||||
Nondiabetic | 1299/4593 | Reference | Reference | Reference | |||
Diabetic | 253/790 | 1.27 (1.11-1.47) | <.001 | 1.26 (1.06-1.48) | .008 | 1.31 (1.00-1.71) | .048 |
Race | |||||||
Black | 295/1001 | Reference | Reference | Reference | |||
White | 1257/4382 | 0.88 (0.77-1.01) | .059 | 0.92 (0.77-1.09) | .331 | 0.83 (0.68-1.02) | .077 |
Gender | |||||||
Female | 630/2381 | Reference | Reference | Reference | |||
Male | 922/3002 | 1.23 (1.10. 1.39) | <.001 | 1.29 (1.14-1.47) | <.001 | 1.14 (0.95-1.36) | .163 |
Age (y) | |||||||
<45 | 55/326 | Reference | Reference | Reference | |||
45-60 | 362/1558 | 1.52 (1.13-2.04) | .006 | 1.59 (1.13-2.25) | <.001 | 1.33 (0.75-2.35) | .007 |
>60 | 1135/3499 | 2.41 (1.82-3.20) | <.001 | 2.51 (1.81-3.50) | .009 | 2.15 (1.23-3.74) | .330 |
BMI | |||||||
Normal | 499/1612 | Reference | Reference | Reference | |||
Overweight | 588/2079 | 0.83 (0.70-0.99) | .035 | 0.77 (0.66-0.90) | .001 | 0.92 (0.75-1.13) | .415 |
Obese | 442/1603 | 0.82 (0.71-0.93) | .003 | 0.81 (0.69-0.96) | .013 | 0.83 (0.66-1.05) | .116 |
Underweight | 23/89 | 1.08 (0.69-1.69) | .725 | 1.09 (0.63-1.89) | .756 | 1.07 (0.50-2.28) | .871 |
Black cohort | |||||||
Diabetes | |||||||
Nondiabetic | 67/247 | Reference | Reference | Reference | |||
Diabetic | 228/754 | 1.08 (0.81-1.44) | .584 | 1.01 (0.70-1.46) | .942 | 1.21 (0.76-1.91) | .428 |
Gender | |||||||
Female | 147/549 | Reference | Reference | Reference | |||
Male | 148/452 | 1.30 (1.03-1.65) | .028 | 1.19 (0.86-1.64) | .286 | 1.44 (1.02-2.03) | .040 |
Age (y) | |||||||
<45 | 16/81 | Reference | Reference | Reference | |||
45-60 | 182/569 | 1.59 (0.92-2.73) | .095 | 1.59 (0.84-3.01) | .030 | 1.58 (0.56-4.42) | .126 |
>60 | 97/351 | 2.03 (1.20-3.42) | .008 | 1.97 (1.07-3.62) | .154 | 2.20 (0.80-6.05) | .387 |
BMI | |||||||
Normal | 96/253 | Reference | Reference | Reference | |||
Overweight | 104/374 | 0.68 (0.52-0.90) | .007 | 0.63 (0.43-0.92) | .016 | 0.75 (0.50-1.14) | .181 |
Obese | 89/361 | 0.62 (0.46-0.83) | .002 | 0.57 (0.38-0.86) | .007 | 0.68 (0.43-1.05) | .083 |
Underweight | 6/13 | 1.88 (0.81-4.33) | .139 | 1.82 (0.65-5.11) | .255 | 1.99 (0.48-8.27) | .347 |
White cohort | |||||||
Diabetes | |||||||
Nondiabetic | 186/543 | Reference | Reference | Reference | |||
Diabetic | 1071/3839 | 1.35 (1.15-1.59) | <.001 | 1.33 (1.11-1.61) | .003 | 1.41 (1.02-1.96) | .040 |
Gender | |||||||
Female | 483/1832 | Reference | Reference | Reference | |||
Male | 774/2550 | 1.16 (0.93-1.46) | .194 | 1.29 (1.12-1.49) | <.001 | 1.02 (0.82-1.26) | .878 |
Age (y) | |||||||
<45 | 39/245 | Reference | Reference | Reference | |||
45-60 | 953/2930 | 1.51 (1.06-2.14) | .023 | 1.63 (1.08-2.46) | <.001 | 1.21 (0.61-2.41) | .032 |
>60 | 265/1207 | 2.51 (1.79-3.53) | <.001 | 2.69 (1.81-4.00) | .022 | 2.07 (1.07-4.03) | .592 |
BMI | |||||||
Normal | 403/1359 | Reference | Reference | Reference | |||
Overweight | 484/1705 | 0.87 (0.70-1.10) | .248 | 0.79 (0.67-0.94) | .006 | 1.00 (0.78-1.27) | .970 |
Obese | 353/1242 | 0.88 (0.76-1.02) | .095 | 0.86 (0.72-1.03) | .095 | 0.93 (0.71-1.21) | .575 |
Underweight | 17/76 | 0.93 (0.55-1.57) | .794 | 0.95 (0.50-1.82) | .880 | 0.90 (0.37-2.21) | .816 |
Bold values indicate P < 0.05.