Relationship between percent GATA2+ bone marrow cells and survival in adult MDS
| MDS group . | OS (mo), median (95% CI) . | GATA2 hazard ratio (95% CI)∗ . | P value . |
|---|---|---|---|
| Overall (n = 47) | 17.2 (12.2-43.8) | 1.12 (1.05-1.18) | <.001 |
| Diagnosis | |||
| MLD (n = 23) | 38.5 (16.5, —) | 1.20 (1.04-1.39) | .015 |
| EB-1 (n = 12) | 10.0 (6.0, —) | 1.04 (0.90-1.17) | .552 |
| EB-2 (n = 12) | 10.4 (7.4, —) | 1.11 (0.98-1.25) | .092 |
| Overall | 1.11 (1.03-1.19) | .009 | |
| IPSS-R category | |||
| Low (n = 13) | 59.5 (38.5, —) | 1.41 (1.06-2.83) | .016 |
| Intermediate (n = 14) | 26.5 (17.2, —) | 0.69 (0.32-1.16) | .182 |
| High (n = 20) | 9.6 (7.4-14.9) | 1.04 (0.95-1.13) | .339 |
| MDS group . | OS (mo), median (95% CI) . | GATA2 hazard ratio (95% CI)∗ . | P value . |
|---|---|---|---|
| Overall (n = 47) | 17.2 (12.2-43.8) | 1.12 (1.05-1.18) | <.001 |
| Diagnosis | |||
| MLD (n = 23) | 38.5 (16.5, —) | 1.20 (1.04-1.39) | .015 |
| EB-1 (n = 12) | 10.0 (6.0, —) | 1.04 (0.90-1.17) | .552 |
| EB-2 (n = 12) | 10.4 (7.4, —) | 1.11 (0.98-1.25) | .092 |
| Overall | 1.11 (1.03-1.19) | .009 | |
| IPSS-R category | |||
| Low (n = 13) | 59.5 (38.5, —) | 1.41 (1.06-2.83) | .016 |
| Intermediate (n = 14) | 26.5 (17.2, —) | 0.69 (0.32-1.16) | .182 |
| High (n = 20) | 9.6 (7.4-14.9) | 1.04 (0.95-1.13) | .339 |
Significance indicated in bold. CI, confidence interval; EB, excess blasts; IPSS-R, Revised International Prognostic Scoring System; MLD, multilineage dysplasia; MDS, myelodysplastic neoplasm; OS, overall survival.
Hazard ratio for a 1% change in percent GATA2+ bone marrow cells.