Retrospective cohort studies comparing direct-acting oral anticoagulants to traditional anticoagulation for patients with cirrhosis including those with deep venous thrombosis and pulmonary embolism
| Retrospective study . | DOACS (n) . | Traditional anticoagulation (n) . |
|---|---|---|
| Intagliata12 | ||
| N | 20 | 19 |
| DVT/PE n (% of N) | 4 (20) | 12 (63) |
| Child Pugh-B (n) | 11 | 10 |
| Child Pugh-C (n) | 0 | 0 |
| Bleeding (n) | 4 | 3 |
| Thrombosis (n) | N/A | N/A |
| Hum13 | ||
| N | 27 | 18 |
| DVT/PE n (% of N) | 12 (39) | 8 (44) |
| Child Pugh-B (n) | 12 | 9 |
| Child Pugh-C (n) | 4 | 2 |
| Bleeding (n) | 8 | 10 |
| Thrombosis (n) | 1 | 1 |
| Jones14 | ||
| N | 42 | 37 |
| DVT/PE n (% of N) | 9 (21) | 8 (22) |
| Child Pugh-B (n) | 8 | 19 |
| Child Pugh-C (n) | 0 | 2 |
| Bleeding (n) | 7 | 8 |
| Thrombosis (n) | 3 | 3 |
| Davis14 | ||
| N | 27 | 82 |
| DVT/PE n (% of N) | 19 (70%) | 62 (76%) |
| Child Pugh-B (n) | 16 | 49 |
| Child Pugh-C (n) | 0 | 15 |
| Bleeding* (n) | 2 | 11 |
| Thrombosis (n) | 3 | 10 |
| Coons15 | ||
| N | 44 | 41 |
| DVT/PE n (% of N) | 11 (25) | 8 (20) |
| Child Pugh-B (n) | 24 | 17 |
| Child Pugh-C (n) | 8 | 9 |
| Bleeding (n) | 10 | 14 |
| Thrombosis (n) | 1 | 2 |
| Aquite15 | ||
| N | 48 | 52 |
| DVT/PE n1 (% of N) | 10 (21) | 11 (21) |
| Child Pugh-B (n) | N/A | N/A |
| Child Pugh-C (n) | N/A | N/A |
| Bleeding (n2) | 9.1/100-patient years | 14.4/100 patient years |
| Thrombosis (n) | N/A | N/A |
| Oldham16 | ||
| N | 67 | 32 |
| DVT/PE n1 (% of N) | 45 (65) | 9 (28) |
| Child Pugh-B (n) | 59 | 30 |
| Child Pugh-C (n) | 0 | 0 |
| Bleeding (n) | 25 | 7 |
| Thrombosis (n) | 3 | 0 |
| Retrospective study . | DOACS (n) . | Traditional anticoagulation (n) . |
|---|---|---|
| Intagliata12 | ||
| N | 20 | 19 |
| DVT/PE n (% of N) | 4 (20) | 12 (63) |
| Child Pugh-B (n) | 11 | 10 |
| Child Pugh-C (n) | 0 | 0 |
| Bleeding (n) | 4 | 3 |
| Thrombosis (n) | N/A | N/A |
| Hum13 | ||
| N | 27 | 18 |
| DVT/PE n (% of N) | 12 (39) | 8 (44) |
| Child Pugh-B (n) | 12 | 9 |
| Child Pugh-C (n) | 4 | 2 |
| Bleeding (n) | 8 | 10 |
| Thrombosis (n) | 1 | 1 |
| Jones14 | ||
| N | 42 | 37 |
| DVT/PE n (% of N) | 9 (21) | 8 (22) |
| Child Pugh-B (n) | 8 | 19 |
| Child Pugh-C (n) | 0 | 2 |
| Bleeding (n) | 7 | 8 |
| Thrombosis (n) | 3 | 3 |
| Davis14 | ||
| N | 27 | 82 |
| DVT/PE n (% of N) | 19 (70%) | 62 (76%) |
| Child Pugh-B (n) | 16 | 49 |
| Child Pugh-C (n) | 0 | 15 |
| Bleeding* (n) | 2 | 11 |
| Thrombosis (n) | 3 | 10 |
| Coons15 | ||
| N | 44 | 41 |
| DVT/PE n (% of N) | 11 (25) | 8 (20) |
| Child Pugh-B (n) | 24 | 17 |
| Child Pugh-C (n) | 8 | 9 |
| Bleeding (n) | 10 | 14 |
| Thrombosis (n) | 1 | 2 |
| Aquite15 | ||
| N | 48 | 52 |
| DVT/PE n1 (% of N) | 10 (21) | 11 (21) |
| Child Pugh-B (n) | N/A | N/A |
| Child Pugh-C (n) | N/A | N/A |
| Bleeding (n2) | 9.1/100-patient years | 14.4/100 patient years |
| Thrombosis (n) | N/A | N/A |
| Oldham16 | ||
| N | 67 | 32 |
| DVT/PE n1 (% of N) | 45 (65) | 9 (28) |
| Child Pugh-B (n) | 59 | 30 |
| Child Pugh-C (n) | 0 | 0 |
| Bleeding (n) | 25 | 7 |
| Thrombosis (n) | 3 | 0 |
DOACs, direct acting oral anticoagulants; DVT, deep venous thrombosis; PE, pulmonary embolism; traditional anticoagulation refers to low-molecular weight heparin or vitamin K antagonists.
Only major bleeding was reported.
Number includes splanchnic vein thrombosis.
Only reported patient-years of bleeding.
Child-Pugh class, bleeding, and thrombosis have been reported for the entire study population (N).