Table 1. Exposure to FY, JK, and Ss... | American Society of Hematology

Table 1.

Exposure to FY, JK, and Ss antigens in the full cohort (N = 6496) and incidence of alloimmunization

Patient phenotype	Patients, n	RBCus, n	RBCs with a phenotype for the antigen			Antibodies
Patient phenotype	Patients, n	RBCus, n	Negative, n, %	Unknown (not determined) n, %	Positive n, %	n, % relative to patients negative for the antigen	% antibodies compared with the number of RBCs positive/not determined for the antigen
Fy(a^–) FY: –1	5845	220 520	47 773 Fy^a– 21.7	121 494 55.1	51 253 Fy^a+ 23.2	99 anti-Fy^a 1.7	0.06% anti-Fy^a per Fy(a⁺) or Fy^a unknown RBC
Fy(b^–) FY: –2	5744	213 690	23 650 Fy^b– 11.1	121 620 56.9	68 420 Fy^b+ 32.0	NA∗	NA∗
Jk(a^–) JK: –1	353	16 203	2835 Jk^a– 17.5	8602 53.1	4766 Jk^a+ 29.4	30 anti-Jk^a 1.1	0.22% anti-Jk^a per Jk(a⁺) or Jk^a unknown RBC
Jk(b^–) JK:–2	3559	137 843	24 005 Jk^b– 17.4	78 544 57.0	35 294 Jk^b+ 25.6	126 anti-Jk^b 3.5	0.11% anti-Jk^b per Jk(b⁺) or Jk^b unknown RBC
S^– MNS: –3	4610	177 097	45 388 S^– 25.6	99 352 56.1	32 357 S⁺ 18.3	181 anti-S 3.9	0.14% anti-S per S⁺ or S unknown RBC
s^– MNS: –4	404	13 791	1051 s^– 7.6	7194 52.2	5546 s⁺ 40.2	9 anti-s 0.8	0.07% anti-s per s⁺ or s unknown RBC

Patient phenotype	Patients, n	RBCus, n	RBCs with a phenotype for the antigen			Antibodies
Patient phenotype	Patients, n	RBCus, n	Negative, n, %	Unknown (not determined) n, %	Positive n, %	n, % relative to patients negative for the antigen	% antibodies compared with the number of RBCs positive/not determined for the antigen
Fy(a^–) FY: –1	5845	220 520	47 773 Fy^a– 21.7	121 494 55.1	51 253 Fy^a+ 23.2	99 anti-Fy^a 1.7	0.06% anti-Fy^a per Fy(a⁺) or Fy^a unknown RBC
Fy(b^–) FY: –2	5744	213 690	23 650 Fy^b– 11.1	121 620 56.9	68 420 Fy^b+ 32.0	NA∗	NA∗
Jk(a^–) JK: –1	353	16 203	2835 Jk^a– 17.5	8602 53.1	4766 Jk^a+ 29.4	30 anti-Jk^a 1.1	0.22% anti-Jk^a per Jk(a⁺) or Jk^a unknown RBC
Jk(b^–) JK:–2	3559	137 843	24 005 Jk^b– 17.4	78 544 57.0	35 294 Jk^b+ 25.6	126 anti-Jk^b 3.5	0.11% anti-Jk^b per Jk(b⁺) or Jk^b unknown RBC
S^– MNS: –3	4610	177 097	45 388 S^– 25.6	99 352 56.1	32 357 S⁺ 18.3	181 anti-S 3.9	0.14% anti-S per S⁺ or S unknown RBC
s^– MNS: –4	404	13 791	1051 s^– 7.6	7194 52.2	5546 s⁺ 40.2	9 anti-s 0.8	0.07% anti-s per s⁺ or s unknown RBC

∗

Exposure to the Fy^b antigen might be compared with anti-Fy3 and/or anti-Fy5 (n = 73; 2 patients were determined to have both anti-Fy3 and anti-Fy5), made by 1.0% of Fy(b^–) patients, that is, 0.04% anti-Fy3 or anti-Fy5 per RBC transfused bearing a Fy(b⁺) or unknown Fy^b phenotype.

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