Table 1. International MDS risk... | American Society of Hematology

Table 1.

International MDS risk stratification systems

Features	IPSS²³	WPSS²⁵	IPSS-R⁴⁵	CCF/ MLL⁶²	EuroMDS⁶⁵	IPSS-M⁶⁸
Patients (n)	816	426	7012	1471	2043	2701
Hemoglobin	+	+	+	+	+	+
Platelets	+	+	+	+	+	+
Absolute neutrophil count	+	+	+
Transfusion dependence		+
BM blast percentage/morphology	+	+	+	+	+	+
Time dependent		+
Cytogenetics	+	+	+	+	+	+
Categories/abnormalities	3/9	3/9	5/17	5/17	5/17	5/17
Gene mutations (n)				+ (24)	+ (63)	+ (31)
Survival, (y, median)
Risk categories	Low, 5.7	Very low, 8.5	Very low, 8.8	0, 5.9	0, 6.5	Very low, 10.6
	Int 1, 3.5	Low, 6	Low, 5.3	1-2, 4.9	1-2, 6.4	Low, 6.0
	Int 2, 1.1	Int, 3.3	Int, 3.0	3-4, 3.0	3-4, 4.0	Mod low, 4.6
	High, 0.4	High, 1.8	High, 1.6	≥5, 1.7	5-6, 2.1	Mod high, 2.8
		Very high, 1.0	Very high, 0.8		≥7, 1.6	High, 1.7
						Very high, 1.0

Features	IPSS²³	WPSS²⁵	IPSS-R⁴⁵	CCF/ MLL⁶²	EuroMDS⁶⁵	IPSS-M⁶⁸
Patients (n)	816	426	7012	1471	2043	2701
Hemoglobin	+	+	+	+	+	+
Platelets	+	+	+	+	+	+
Absolute neutrophil count	+	+	+
Transfusion dependence		+
BM blast percentage/morphology	+	+	+	+	+	+
Time dependent		+
Cytogenetics	+	+	+	+	+	+
Categories/abnormalities	3/9	3/9	5/17	5/17	5/17	5/17
Gene mutations (n)				+ (24)	+ (63)	+ (31)
Survival, (y, median)
Risk categories	Low, 5.7	Very low, 8.5	Very low, 8.8	0, 5.9	0, 6.5	Very low, 10.6
	Int 1, 3.5	Low, 6	Low, 5.3	1-2, 4.9	1-2, 6.4	Low, 6.0
	Int 2, 1.1	Int, 3.3	Int, 3.0	3-4, 3.0	3-4, 4.0	Mod low, 4.6
	High, 0.4	High, 1.8	High, 1.6	≥5, 1.7	5-6, 2.1	Mod high, 2.8
		Very high, 1.0	Very high, 0.8		≥7, 1.6	High, 1.7
						Very high, 1.0

CCF, Cleveland Clinic Foundation; int1, intermediate 1; int2, intermediate 2; MLL, Munich Leukemia Laboratory; mod, moderate.