Minimum FVIII level to prevent total and spontaneous joint bleeds
| Outcomes for all joint bleeds . | AUC . | YI . | FVIII level . |
|---|---|---|---|
| At least 1 joint bleeding episode in life∗ | 0.73 | 0.39 | 19.2 |
| At least 1 joint bleeding episode in the 1st quartile of age (<28)† | 0.68 | 0.34 | 19.2 |
| At least 1 joint bleeding episode in the 2nd quartile of age (28 ≤ x < 45)‡ | 0.73 | 0.41 | 14.0 |
| At least 1 joint bleeding episode in the 3rd quartile of age (45 ≤ x < 59)§ | 0.71 | 0.41 | 12.8 |
| At least 1 joint bleeding episode in the 4th quartile of age (≥59)‖ | 0.80 | 0.47 | 14.3 |
| Outcomes for spontaneous joint bleeds | |||
| At least 1 spontaneous joint bleeding episode in life¶ | 0.80 | 0.58 | 17.7 |
| At least 1 spontaneous joint bleed in the 1st quartile of age (<28)# | 0.85 | 0.67 | 17.7 |
| At least 1 spontaneous joint bleed in the 2nd quartile of age (28 ≤ x < 45)∗∗ | 0.88 | 0.71 | 16.7 |
| At least 1 spontaneous joint bleed in the 3rd quartile of age (45 ≤ x < 59)†† | NA | NA | NA |
| At least 1 spontaneous joint bleed in the 4th quartile of age (≥59)‡‡ | 0.92 | 0.87 | 12.8 |
| Outcomes for all joint bleeds . | AUC . | YI . | FVIII level . |
|---|---|---|---|
| At least 1 joint bleeding episode in life∗ | 0.73 | 0.39 | 19.2 |
| At least 1 joint bleeding episode in the 1st quartile of age (<28)† | 0.68 | 0.34 | 19.2 |
| At least 1 joint bleeding episode in the 2nd quartile of age (28 ≤ x < 45)‡ | 0.73 | 0.41 | 14.0 |
| At least 1 joint bleeding episode in the 3rd quartile of age (45 ≤ x < 59)§ | 0.71 | 0.41 | 12.8 |
| At least 1 joint bleeding episode in the 4th quartile of age (≥59)‖ | 0.80 | 0.47 | 14.3 |
| Outcomes for spontaneous joint bleeds | |||
| At least 1 spontaneous joint bleeding episode in life¶ | 0.80 | 0.58 | 17.7 |
| At least 1 spontaneous joint bleed in the 1st quartile of age (<28)# | 0.85 | 0.67 | 17.7 |
| At least 1 spontaneous joint bleed in the 2nd quartile of age (28 ≤ x < 45)∗∗ | 0.88 | 0.71 | 16.7 |
| At least 1 spontaneous joint bleed in the 3rd quartile of age (45 ≤ x < 59)†† | NA | NA | NA |
| At least 1 spontaneous joint bleed in the 4th quartile of age (≥59)‡‡ | 0.92 | 0.87 | 12.8 |
FVIII level indicates the minimum (trough) FVIII level to achieve zero joint bleeds (total or spontaneous).
NA, non applicable; YI, Youden Index (sensitivity + specificity – 1).
Available in 270 patients.
Available in 266 patients.
Available/applicable in 203 patients.
Available/applicable in 130 patients.
Available/applicable in 66 patients
Available in 240 patients.
Available in 238 patients.
Available/applicable in 180 patients.
Available/applicable in 115 patients.
Available/applicable in 56 patients.