Association between mean FVIII level and joint bleeding frequency
| . | Logistic regression models for “at least 1 joint bleed in life” . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 270) . | Multivariate∗ (n = 270) . | Multivariate† (n = 192) . | ||||
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Mean FVIII:C | 0.93 (0.90-0.95) | <.0001 | 0.93 (0.90-0.95) | <.0001 | 0.92 (0.89-0.95) | <.0001 |
| . | Logistic regression models for “at least 1 joint bleed in life” . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 270) . | Multivariate∗ (n = 270) . | Multivariate† (n = 192) . | ||||
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Mean FVIII:C | 0.93 (0.90-0.95) | <.0001 | 0.93 (0.90-0.95) | <.0001 | 0.92 (0.89-0.95) | <.0001 |
| . | Logistic regression models for “at least 1 spontaneous joint bleed in life” . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 240) . | Multivariate∗ (n = 240) . | Multivariate† (n = 170) . | ||||
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Mean FVIII:C | 0.88 (0.80-0.97) | .001 | 0.88 (0.79 – 0.97) | .0008 | 0.76 (0.60-0.96) | .0005 |
| . | Logistic regression models for “at least 1 spontaneous joint bleed in life” . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 240) . | Multivariate∗ (n = 240) . | Multivariate† (n = 170) . | ||||
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Mean FVIII:C | 0.88 (0.80-0.97) | .001 | 0.88 (0.79 – 0.97) | .0008 | 0.76 (0.60-0.96) | .0005 |
| . | Negative binomial regression models for AJBR . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 262) . | Multivariate∗ (n = 262) . | Multivariate† (n = 187) . | ||||
| AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | |
| Mean FVIII:C | 0.94 (0.92-0.96) | <.0001 | 0.94 (0.92-0.96) | <.0001 | 0.93 (0.91-0.96) | <.0001 |
| . | Negative binomial regression models for AJBR . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 262) . | Multivariate∗ (n = 262) . | Multivariate† (n = 187) . | ||||
| AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | |
| Mean FVIII:C | 0.94 (0.92-0.96) | <.0001 | 0.94 (0.92-0.96) | <.0001 | 0.93 (0.91-0.96) | <.0001 |
| . | Negative binomial regression models for spontaneous AJBR . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 237) . | Multivariate∗ (n = 237) . | Multivariate† (n = 168) . | ||||
| AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | |
| Mean FVIII:C | 0.892 (0.798-0.997) | .0437 | 0.89 (0.79-0.97) | .0453 | 0.66 (0.45-0.95) | .0264 |
| . | Negative binomial regression models for spontaneous AJBR . | |||||
|---|---|---|---|---|---|---|
| Univariate (n = 237) . | Multivariate∗ (n = 237) . | Multivariate† (n = 168) . | ||||
| AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | AJBRR (95% CI) . | P value . | |
| Mean FVIII:C | 0.892 (0.798-0.997) | .0437 | 0.89 (0.79-0.97) | .0453 | 0.66 (0.45-0.95) | .0264 |
AJBR was calculated considering the time of observation of the patient’s entire life (age at the last follow-up). For spontaneous AJBR, only spontaneous bleeds were considered.
AJBRR, annualized joint bleeding rate ratio; FVIII:C, factor VIII coagulant activity; OR, odds ratio.
Adjusted for age.
Adjusted for age and ABO blood group.