Main patient characteristics and joint bleeding phenotype
| . | N=270 . |
|---|---|
| Age at last follow-up, mean (SD), y | 45.6 (19.9) |
| FVIII:C, mean (SD), IU/dL∗ | 23.5 (12.1) |
| Time of observation for other bleeds, mean (SD), y† | 13.4 (3.8) |
| No zero blood group, n (%)‡ | 115 (59.9) |
| All joint bleeding episodes | |
| At least 1 joint bleeding episode in life, n (%) | 100 (37) |
| At least 1 joint bleeding episode in the 1st quartile of age (<28), n (%)§ | 60 (22.6) |
| At least 1 joint bleeding episode in the 2nd quartile of age (28 ≤ x < 45), n (%)‖ | 25 (12.3) |
| At least 1 joint bleeding episode in the 3rd quartile of age (45 ≤ x < 59), n (%)¶ | 10 (7.7) |
| At least 1 joint bleeding episode in the 4th quartile of age (≥59), n (%)# | 14 (21.2) |
| Spontaneous joint bleeding episodes | |
| At least 1 spontaneous joint bleeding episode in life, n (%)∗∗ | 10 (4.2) |
| At least 1 spontaneous joint bleeding episode in the 1st quartile of age (<28), n (%)†† | 3 (1.3) |
| At least 1 spontaneous joint bleeding episode in the 2nd quartile of age (28 ≤ x < 45), n (%)‡‡ | 3 (1.7) |
| At least 1 spontaneous joint bleeding episode in the 3rd quartile of age (45 ≤ x < 59), n (%)§§ | 0 |
| At least 1 spontaneous joint bleeding episode in the 4th quartile of age (≥59), n (%)‖‖ | 3 (5.4) |
| . | N=270 . |
|---|---|
| Age at last follow-up, mean (SD), y | 45.6 (19.9) |
| FVIII:C, mean (SD), IU/dL∗ | 23.5 (12.1) |
| Time of observation for other bleeds, mean (SD), y† | 13.4 (3.8) |
| No zero blood group, n (%)‡ | 115 (59.9) |
| All joint bleeding episodes | |
| At least 1 joint bleeding episode in life, n (%) | 100 (37) |
| At least 1 joint bleeding episode in the 1st quartile of age (<28), n (%)§ | 60 (22.6) |
| At least 1 joint bleeding episode in the 2nd quartile of age (28 ≤ x < 45), n (%)‖ | 25 (12.3) |
| At least 1 joint bleeding episode in the 3rd quartile of age (45 ≤ x < 59), n (%)¶ | 10 (7.7) |
| At least 1 joint bleeding episode in the 4th quartile of age (≥59), n (%)# | 14 (21.2) |
| Spontaneous joint bleeding episodes | |
| At least 1 spontaneous joint bleeding episode in life, n (%)∗∗ | 10 (4.2) |
| At least 1 spontaneous joint bleeding episode in the 1st quartile of age (<28), n (%)†† | 3 (1.3) |
| At least 1 spontaneous joint bleeding episode in the 2nd quartile of age (28 ≤ x < 45), n (%)‡‡ | 3 (1.7) |
| At least 1 spontaneous joint bleeding episode in the 3rd quartile of age (45 ≤ x < 59), n (%)§§ | 0 |
| At least 1 spontaneous joint bleeding episode in the 4th quartile of age (≥59), n (%)‖‖ | 3 (5.4) |
FVIII:C, factor VIII coagulant activity.
For each patient, the mean level of all the FVIII:C dosages performed in life by 1 stage clotting assay.
For each patient, the period between January 2005 and the date of last follow-up. This time of observation was considered for other than joint bleeds. For joint bleeds we considered as time of observation the whole life (age at last follow-up).
Available in 192 patients.
Available in 266 patients.
Available/applicable in 203 patients.
Available/applicable in 130 patients.
Available/applicable in 66 patients.
Available in 240 patients.
Available in 238 patients.
Available/applicable in 180 patients.
Available/applicable in 115 patients.
Available/applicable in 56 patients.