Characteristics of patients with and without TP53 mutations
Characteristic . | TP53 mutation, % (n = 42) . | No TP53 mutation, % (n = 75) . | P . |
---|---|---|---|
Median age (y) | 65 | 58 | .08 |
IPI score ≥ 3 | 57 | 35 | .03 |
HGBL histology | 31 | 12 | .02 |
Prior indolent lymphoma | 14 | 15 | 1.00 |
GCB cell of origin | 57 | 46 | .33 |
MYC rearrangement | 31 | 14 | .05 |
MYC-BCL2 double hit | 14 | 7 | .33 |
SOCS1 mutation | 19 | 28 | .37 |
B2M mutation | 17 | 23 | .49 |
CREBBP mutation | 27 | 15 | .09 |
TNFRSF14 mutation | 26 | 12 | .07 |
TBL1XR1 mutation | 15 | 17 | 1.00 |
GNA13 mutation | 19 | 12 | .41 |
MYC mutation | 12 | 14 | 1.00 |
CIITA mutation | 7 | 15 | .37 |
DICER1 mutation | 19 | 5 | .12 |
BCL2 mutation | 15 | 8 | .44 |
EZH2 mutation | 19 | 7 | .06 |
ATM mutation | 12 | 11 | 1.00 |
TNFAIP3 mutation | 10 | 11 | 1.00 |
CARD11 mutation | 10 | 11 | 1.00 |
Other genetic subtype | 62 | 74 | .21 |
EZB genetic subtype | 33 | 15 | .04 |
MCD genetic subtype | 5 | 4 | 1.00 |
ST2 genetic subtype | 0 | 7 | .16 |
Characteristic . | TP53 mutation, % (n = 42) . | No TP53 mutation, % (n = 75) . | P . |
---|---|---|---|
Median age (y) | 65 | 58 | .08 |
IPI score ≥ 3 | 57 | 35 | .03 |
HGBL histology | 31 | 12 | .02 |
Prior indolent lymphoma | 14 | 15 | 1.00 |
GCB cell of origin | 57 | 46 | .33 |
MYC rearrangement | 31 | 14 | .05 |
MYC-BCL2 double hit | 14 | 7 | .33 |
SOCS1 mutation | 19 | 28 | .37 |
B2M mutation | 17 | 23 | .49 |
CREBBP mutation | 27 | 15 | .09 |
TNFRSF14 mutation | 26 | 12 | .07 |
TBL1XR1 mutation | 15 | 17 | 1.00 |
GNA13 mutation | 19 | 12 | .41 |
MYC mutation | 12 | 14 | 1.00 |
CIITA mutation | 7 | 15 | .37 |
DICER1 mutation | 19 | 5 | .12 |
BCL2 mutation | 15 | 8 | .44 |
EZH2 mutation | 19 | 7 | .06 |
ATM mutation | 12 | 11 | 1.00 |
TNFAIP3 mutation | 10 | 11 | 1.00 |
CARD11 mutation | 10 | 11 | 1.00 |
Other genetic subtype | 62 | 74 | .21 |
EZB genetic subtype | 33 | 15 | .04 |
MCD genetic subtype | 5 | 4 | 1.00 |
ST2 genetic subtype | 0 | 7 | .16 |
GCB, Germinal center B.