Comparison of presenting clinical and laboratory findings in iTTP and aHUS
| . | Immune TTP6,7 . | aHUS (adult)8,9,44 . |
|---|---|---|
| Adult or childhood onset | More common in adults (Congenital TTP more common in children) | Similar prevalence of adults and children |
| MAHA with thrombocytopenia | 100% | ~85% |
| Neurologic findings | Overall, 67%-78% Seizure, 7%-8% Coma, 3%-10% Stroke, 5%-10% | Overall, 8%-43% |
| Thrombocytopenia | More severe Median: 10-15 × 109/L | Less severe Median: 57-118 × 109/L |
| Renal dysfunction | Less severe Median serum creatinine: 1.09-1.3 mg/dL | More severe Median serum creatinine: 2.9-4.6 mg/dL |
| Severe (or malignant) hypertension | N/A, uncommon | Common, 8%-54% |
| Cardiac involvement | 42% | 19% |
| Fever | 10%-24% | Not reported |
| Abdominal symptoms | 35% | 15% |
| ADAMTS13 activity (%), median (range)16 | 5 (0-11) | 66.5 (12-119) |
| . | Immune TTP6,7 . | aHUS (adult)8,9,44 . |
|---|---|---|
| Adult or childhood onset | More common in adults (Congenital TTP more common in children) | Similar prevalence of adults and children |
| MAHA with thrombocytopenia | 100% | ~85% |
| Neurologic findings | Overall, 67%-78% Seizure, 7%-8% Coma, 3%-10% Stroke, 5%-10% | Overall, 8%-43% |
| Thrombocytopenia | More severe Median: 10-15 × 109/L | Less severe Median: 57-118 × 109/L |
| Renal dysfunction | Less severe Median serum creatinine: 1.09-1.3 mg/dL | More severe Median serum creatinine: 2.9-4.6 mg/dL |
| Severe (or malignant) hypertension | N/A, uncommon | Common, 8%-54% |
| Cardiac involvement | 42% | 19% |
| Fever | 10%-24% | Not reported |
| Abdominal symptoms | 35% | 15% |
| ADAMTS13 activity (%), median (range)16 | 5 (0-11) | 66.5 (12-119) |